The Intestine Volume 2: The Intestine Stem Cell Innovation in Health & Disease Series
Coordonnateurs : El-Hashash Ahmed, Meguid Eiman Abdel
The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.
Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.
Section 1: Cutting edge research on the intestinal stem cell functions 1. Intestinal organoid cell culture as a new modality to intestinal function, cellular processes and stem cell functions 2. Intestinal organoids in gastrointestinal pathology
Section 2: Cutting edge research on stem cell application in the intestinal diseases (from bench to bed) 3. Intestinal organoid culture as a new test-bed for intestinal therapeutic research and development 4. Engineered stem cells combine stem cell and gene therapy approaches to move intestine therapy from bench to bed 5. Application of CRISPR/Cas9 and other gene editing/ engineering technology in intestine diseases 6. New approaches for intestine and colon repair via stem cell-based tissue engineering 7. iPSCs and intestine diseases from bench to bed 8. The potential of embryonic stem cells for treating intestinal diseases from bench to bed 9. Stem-cell therapy with bone marrow (hematopoietic) stem cells for intestinal diseases 10. Mesenchymal and other stem cell-therapy of intestinal diseases
She completed her PhD thesis at Eberhard-Karls Universität Tübingen, Germany. Dr Abdel Meguid is an innovative educator and researcher and has published multiple scientific works in leading journals and is a reviewer and a member of the editorial board of a number of journals. Dr Abdel Meguid taught gross anatomy to medical, dental, human biology students and students enrolled in MSc in clinical anatomy. Her research interests are in the areas of stem cells, lung development, anatomical pedagogy, teaching strategies, and the integration of novel technologies to enhance learning.
- Provides intensive scientific background and most recent information on cutting edge research to understand intestinal stem cell functions and develop methods to bring stem cells from bench to bedside for different intestinal diseases
- Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and the CRISPR gene editing system in the intestine
- Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the intestine
Date de parution : 06-2021
Ouvrage de 204 p.
19x23.4 cm
Thème de The Intestine :
Mots-clés :
Accessory digestive organs; Bone marrow transplantation; Colonoid; Colorectal cancer; Crohn's disease; Decellularization; Embryonic stem cells; Enteroid; GVHD; Gastrointestinal diseases; Gene therapy; Gene-edited stem cells; Genetic editing; Genetic engineering; Hematopoietic stem cells; Hirschsprung disease; Induced pluripotent stem cells; Inflammatory bowel disease; Inflammatory bowel disease; Intestinal diseases; Intestinal function; Intestinal organoid; Intestinal stem cells; Intestine; Leukemia inhibitory factor; Mesenchymal stem cell; Organ-on-chip; Organoid cultures; Parenteral nutrition; Regeneration; Repair; Short bowel syndrome; Small intestine; Stem cell; Stem cell therapy; Stem cells; Tissue; Tissue engineering; Transplantation