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The Lung Volume 1: The Lung Stem Cell Innovation in Health & Disease Series

Langue : Anglais

Auteur :

Couverture de l’ouvrage The Lung

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.

Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world.

Cutting edge Research on the lung stem cell functions1. Lung organoid-based modality of lung function, cellular processes and stem cell functions2. Pulmonary organoid culture system in pulmonary pathology and genetic screening

Cutting edge Research on stem cell application in the lung diseases (from bench to bed)3. Pulmonary organoid culture as innovative test-bed for basic and translational approaches (e.g., disease modeling, drug screening, etc.)4. Contributions of lung stem cell engineering to disease-specific cell line models and new therapies of lung diseases5. Preclinical and clinical applications of innovative gene editing technologies (ZFN, TALEN and CRISPR/Cas9 systems) in respiratory diseases6. iPSCs as an inexhaustible source of disease- or patient-specific stem cell models for lung development, disease and therapy and drug development from bench to bed7. The gold standard embryonic stem cells in lung repair and diseases8. Hematopoietic stem cell roles in the treatment of respiratory diseases9. Clinical potentials of human mesenchymal stem and mesenchymal stromal cells in lung diseases10. General Discussion, Conclusion Remarks and Future Direction

Dr. El-Hashash is a fellow of the California Institute of Regenerative Medicine and New York University Medical School. Prof. El-Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Children’s Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California. In 2016, Prof. El-Hashash joined The University of Edinburgh, Edinburgh Medical School-Zhejiang International Campus, as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. Prof. El-Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine and has published more than 25 papers in international journals and serves as an editorial board member of repute. He is the editor or author of several books on stem cell and regenerative medicine.
  • Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases
  • Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung
  • Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung