Protein-Protein Interactions in Human Disease, Part B Advances in Protein Chemistry and Structural Biology Series

Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field.

1. Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug DesignSitanshu S. Singh and Seetharama D. Jois2. Targeting Intramembrane Protein–Protein Interactions: Novel Therapeutic Strategy of Millions Years OldAlexander B. Sigalov3. Targeting the Architecture of Deregulated Protein Complexes in CancerEduard Stefan, Jakob Troppmair and Klaus Bister4. Multifaceted Nucleolin Protein and Its Molecular Partners in OncogenesisIva Ugrinova, Maria Petrova, Mounira Chalabi-Dchar and Philippe Bouvet5. Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal MotifsCarlos Costas-Insua, Javier Merino-Gracia, Clara Aicart-Ramos and Ignacio Rodríguez-Crespo6. Development of Protein–Protein Interaction Inhibitors for the Treatment of Infectious DiseasesAndrew F. Voter and James L. Keck7. Defining Pharmacological Targets by Analysis of Virus–Host Protein InteractionsManuel Llano and Mario A. Peña-Hernandez8. Investigating the Influence of Hotspot Mutations in Protein–Protein Interaction of IDH1Homodimer Protein: A Computational ApproachD. Thirumal Kumar, P. Sneha, Jennifer Uppin, S. Usha and C. George Priya Doss9. Human Interactomics: Comparative Analysis of Different Protein Interaction Resources andConstruction of a Cancer Protein–Drug Bipartite NetworkJavier De Las Rivas, Diego Alonso-López and Mónica M. Arroyo

The aim of this volume is to promote further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and to identify new protein targets for drug development. Thus, this volume would be of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in this field. Articles published here would also be of a great benefit to medical, biology and pharmacology students specializing in this field.

• Describes advances in the application of powerful techniques in studying and analyzing protein-protein interactions
• Ideal for a wide audience of researchers, specialists and students
• Written by authorities in their field
• Contains a number of high quality illustrations, figures and tables that support the presented information