Protein Interactions as Targets in Drug Discovery

Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.

1. Latest trends in structure based drug design with protein targets Angshuman Bagchi 2. From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD) Stefano Moro 3. Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis M. Michael Gromiha 4. Aromatic-aromatic interactions in protein-drug and protein-protein interactions Adrian Gustavo Turjanski 5. Role of protein-protein interaction in allosteric drug design within the human methyltransferome Guang Hu 6. Protein-Protein Interactions as the Basis for Cyclin-Dependent Kinase Inhibition Mark Klein 7. Targeting FOXP3 complex ensemble in drug discovery Bin Li 8. Targeting arrestin interactions with its partners for therapeutic purposes Vsevolod V. Gurevich 9. Protein interactomics in kidney stone research Visith Thongboonkerd 10. Human oral microbiome protein-protein interaction: a cross-talk with health systemic implications Marlene M.T. Barros 11. Protein-protein complexes as targets for drug discovery against infectious diseases Yusuf Akhter 12. Therapeutic intervention of protein-protein interactions in innate immunity Kevin J. Lumb 13. Physicochemical determinants of antibody-protein interactions Sibel Kalyoncu Uzunlar

This volume would be of great interest to a very wide audience - protein chemists, molecular cell biologists, immunologists, structural biologists, computational biochemists, medical doctors, pharmacologists and other researchers working in the field of protein interactions. Articles published here would also be of a considerable benefit to medical, biology and pharmacology students specializing in this field.

• Integrates experimental and computational methods for studying protein interactions and their modulation by potential therapeutics
• Contains timely chapters written by well-renown authorities in their field
• Covers information that is well supported by a number of high quality illustrations, figures and tables
• Targets a very wide audience of specialists, researchers and students