Molecules, Systems and Signaling in Liver Injury, Softcover reprint of the original 1st ed. 2017 Cell Death in Biology and Diseases Series

This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecul

1.Lipotoxicity in non-parenchymal liver cells.- 2.The Role of Cholangiocyte Cell Death in the Development of Biliary Diseases.- 3.Cell Death and Autophagy in Hepatic Stellate Cell Activation and Function.- 4.The Switch: Mechanisms Governing Macrophage Phenotypic Variability in Liver Disease.- 5.Regulation of apoptosis by Bcl-2 family proteins in liver injury.- 6.Beta-Catenin And The Survival Of Hepatocytes.- 7.Nuclear DAMPs in Hepatic Injury and Inflammation.- 8.The Critical Role of Mitochondria in Drug-Induced Liver Injury.- 9.Mitochondrial Damage and Mitophagy in Ischemia/Reperfusion-Induced Liver Injury.- 10.Role Of Endoplasmic Reticulum Stress In Hepatic Injury.- 11.The Impact Of Gut Microbiota On Liver Injury.

Dr. Wen-Xing Ding is an Associate Professor of Department of Pharmacology, Toxicology and Therapeutics at The University of Kansas Medical Center. He received his Ph.D. from the National University of Singapore. He did his Postdoctoral training at University of Pittsburgh. In the past decade, Dr. Ding’s research has been focused on the molecular mechanisms of cell death and autophagy in alcohol and drug-induced liver injury as well as liver tumorigenesis. Dr. Ding is a member of American Association of Studies of Liver Disease (AASLD), Society of Toxicology (SOT) and Research society of Alcoholism. Dr. Ding was a Liver Scholar of American Liver Foundation and a recipient of University Scholarly Achievement Award. Dr. Ding has published more than 100 papers in peer-reviewed journals and his research work is currently supported by NIAAA and NIDDK.

Dr. Xiao-Ming Yin is the Louis Y. Mazzini Professor of Pathology at the Department of Pathology and Laboratory Medicine,

Provides thorough, comprehensive discussion of the topic with enough breadth to appeal to scientists, clinicians and those doing research for drug discovery

Contributors contribute worldwide expertise and perspective and are all leaders in their fields

Illustrations and tables throughout enhance and complement the text