Functional Metabolism Regulation and Adaptation

Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics.
This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Preface.

Contributors.

Chapter 1: Principles of Metabolic Control (William C. Plaxton).

Chapter 2: Enzymes: The Basis of Catalysis (Stephen P.J. Brooks).

Chapter 3: Enzymes in the Cell: What's Really Going On? (Stephen P.J. Brooks).

Chapter 4: Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli (Justin A. MacDonald).

Chapter 5: Tyrosine Phosphorylation and the Control of Cellular Information (Justin A. MacDonald).

Chapter 6: Control of Transcription in Eukaryotic Cells (William G. Willmore).

Chapter 7: Translational Controls and Protein Synthesis in Eukaryotic Cells (William G. Willmore).

Chapter 8: The Mitochondria: Powerhouse of the Cell (Kyra J. Cowan).

Chapter 9: Human Energy Metabolism in Health and Disease (Steven C. Greenway).

Chapter 10: Hormones in Human Metabolism and Disease (Steven C. Greenway)

Chapter 11: Skeletal Muscle Metabolism and Plasticity (Denis R. Joanisse).

Chapter 12: Oxygen in Biology and Biochemistry: Role of Free Radicals (Marcelo Hermes-Lima).

Chapter 13: Oxidative Stress and Medical Sciences (Marcelo Hermes-Lima).

Chapter 14: Biochemical Adaptation (Kenneth B. Storey).

Chapter 15: Oxygen Limitation and Metabolic Rate Depression (Kenneth B. Storey and Janet M. Storey).

Chapter 16: Mammalian Hibernation: Biochemical Adaptation and Gene Expression (Kenneth B. Storey and Janet M. Storey).

Chapter 17: Cold Hardiness and Freeze Tolerance (Janet M. Storey and Kenneth B. Storey).

Chapter 18: Aspects of Blood Cell Biochemistry: Erythrocytes, Platelets, and Stem Cells (Jean E. Grundy).

Chapter 19: Organ Preservation for Transplantation (Thomas A. Churchill).

Chapter 20: Metabolic Evolution and the Origin of Life (Tolga Bilgen).

Ken Storey?is a Professor in the Institute of Biochemistry at Carleton University and holds the Canada Research Chair in Molecular Physiology. His research focuses on the molecular adaptations that permit animals to survive severe environmental stresses and his work has explored the many intriguing ways that animals alter their metabolism, modify enzyme function, and regulate gene expression to endure deep cold, oxygen deprivation and water restriction, or meet the multiple demands of muscle exercise metabolism. The author of over 450 research publications and the editor of 5 other books, Dr. Storey has lectured on biochemical adaptation on every continent and has done research in places as diverse as the Amazon jungle and the Antarctic ice shelf. He has received multiple fellowships and awards and is an elected fellow of the Royal Society of Canada and of the American Association for the Advancement of Science.