Cell Biology of the Ovary, 1st ed. 2018 Stem Cells, Development, Cancer, and Clinical Aspects

This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer.  

Part I. Development of ovary; 1. Reconstitution of human germ cell development in vitro.- 2. Regulation of steroidogenesis in gonads by Ad4BP/SF-1.-  3. Role of Hedgehog-BMP4 signaling in gonadogenesis.- Part II. Ovarian stem cells and cancer stem cells; 4. Role of Lgr5-expressing stem cells in epithelial renewal and cancer in reproductive tract.- 5. Characteristics of ovarian cancer stem cells.-  6. Role of CD44 variant 6 in ovarian cancer stem cells.- Part III. Strategies for fertility preservation; 7. Rescue from primary ovarian insufficiency.- 8. Ovarian tissue cryopreservation and transplantation.-  9. Clinical management of primary ovarian insufficiency.- Part IV. Molecular and clinical aspects of epithelial ovarian cancer; 10. Molecular pathogenesis of epithelial ovarian cancer.-  11. Clinical management of epithelial ovarian cancer.- 12. Molecular targeted therapy for epithelial ovarian cancer.  

Dr. Hidetaka Katabuchi,

Professor and Chairman,

Department of Obstetrics and Gynecology,

Faculty of Life Sciences,

Kumamoto University

Dr. Takashi Ohba,

Associate Professor,

Department of Obstetrics and Gynecology,

Faculty of Life Sciences,

Kumamoto University

  

Dr. Takeshi Motohara,

Assistant Professor,

Department of Obstetrics and Gynecology,

Faculty of Life Sciences,

Kumamoto University

Provides latest insights into the ovary from basic to clinical aspects Reveals recent findings on ovarian-related cells Enriches understanding of stem cell biology of the ovary