Cancer Treatment and the Ovary Clinical and Laboratory Analysis of Ovarian Toxicity
Coordonnateurs : Anderson Richard A, Spears Norah
Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity provides the reader with a basic understanding on how the ovary is adversely impacted by cancer treatment, an essential foundational knowledge for this rapidly-developing field.
The book describes both the clinical and laboratory approaches to discovering the potentially adverse effects of cancer treatment on the ovary, also laying out possible preventative approaches and future directions for the field.
Clinicians working in the field of reproductive biology and oncology will find an essential reference that provides the necessary tools to assess the reproductive toxicological effects of cancer treatments.
Section I: Clinical
1. Ovarian Follicle Biology and the Basis for Gonadotoxicity 2. Relevant Cancer Diagnoses, Commonly Used Chemotherapy Agents and Their Biochemical Mechanisms of Action 3. Clinical Assessment of Ovarian Toxicity 4. The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment
Section II: Laboratory Models
5. In Vivo Models of Ovarian Toxicity 6. In Vitro Models of Ovarian Toxicity
Section III: Strategies to Protect the Ovary
7. Ovarian Tissue Cryopreservation for Fertility Preservation 8. Current Clinical Approaches to Protecting the Ovary: GnRH Analogues 9. Preclinical Approaches to the Protection of Ovarian Function
Dr. Spears studied for her BSc (Hons) at the University of Edinburgh, followed by a DPhil at Oxford University, supervised by John Clarke. After two years in Irv Zucker’s laboratory at the University of California at Berkeley, and a year in the Brain Metabolism Unit in Edinburgh, she moved to Physiology at the University of Edinburgh. She has worked there since 1990, using animal models to investigate reproductive physiology, holding an MRC Training Fellowship, followed by a Royal Society University Research Fellowship, until she took up a University position in the Centre for Integrative Physiology in 2002. Her current work investigates the effects of chemotherapy treatment on female and male gonads, using a variety of tissue culture techniques.
- Brings together an international group of experts to address the current state of the science of ovarian toxicity caused by cancer treatment
- Provides scientific, clinical, and preclinical approaches to assessing this toxicity
- Describes current techniques and future strategies to protect the ovary
- Ideal reference for the further study of ovarian toxicity, oncofertility, cancer treatment, and reproductive toxicology
Date de parution : 10-2015
Ouvrage de 166 p.
15x22.8 cm
Thèmes de Cancer Treatment and the Ovary :
Mots-clés :
Ovarian toxicity; ovary; oncofertility; cancer treatment; reproductive toxicology
