Sensory Science and Chronic Diseases, 1st ed. 2021 Clinical Implications and Disease Management

Preface.- 1. Taste and Smell Systems Development during infancy, childhood.-  2.Anatomy, Physiology and Neurobiology of Olfaction and Gustation.- 3.Measurement of Olfaction : Screening and assessment.- 4.Measurements of Gustation: Screening and assessment.-  5. Measurements of Chemesthesis.- 6.Integration of taste, smell and chemestesis: Clinical Implications.- 7.Overview of olfaction and gustation under metabolic influences.- 8.Studies on the sense of smell and taste in individuals with obesity.- 9. Studies on the sense of smell and taste in individuals with diabetes.- 10.Studies on the sense of smell and taste in individuals with hypertension.- 11.Studies on the sense of smell and taste in psychiatric disorders.- 12.Taste and Smell alterations and Neurodegenarative Disorders.- 13. Taste and smell in weight loss surgery 3.- 14. Taste and Smell alterations and Cancer Therapies.- 15.Oral health and chemosensory problems.- 16. Chemosensation and pharmacological treatments.- 17. Oral and Extraoral Olfactory and Taste Receptors.- 18. Sensory Nutrition. Implications to Health and Personalized Medicine.- 19.Oral health and Microbiome: Implications for Taste. 

Paule Joseph, PhD, RN, MS, CRNP, FAAN is a Lasker Clinical Research Scholar, Tenure Track Clinical Investigator and Chief of the Section of Sensory Science and Metabolism Unit (SenSMet) in the National Institute on Alcohol Abuse and Alcoholism,  Division of Intramural Clinical and Biological Research (DICBR)  with a joint appointment at National Institute of Nursing Research(NINR) .  She is is also a 2018 NIH Distinguished Scholar. Dr. Joseph is conducting preclinical, clinical, and translational studies to improve the diagnosis, prevention, and management of chemosensory disorders. The Section of Sensory Science and Metabolism (SenSMet) aims to understand neurological and molecular mechanisms underlying chemosensation (taste, smell & chemesthesis) and motivational pathways of ingestive behaviors how they might be different in individuals with obesity and alcohol and substance use disorders. Her laboratory is particularly interested in studying how the brain incorporates chemosensory information from the external environment and its internal states to guide eating/ingestive behavior. To achieve this goal, her laboratory conducts clinical-translational inpatient and outpatient studies. We use a combination of biobehavioral and innovative validated psychophysical methods for human studies. Her laboratory also use imaging brain techniques, such as fMRI for olfaction and gustation. To provide mechanistic insight into our clinical research, her laboratory is also conducting preclinical studies using rodent models to understand cellular and molecular mechanisms that influence how the brain perceives the chemical senses (taste, smell, chemesthesis) and feeding behavior in a state of disease (e.g., obesity and substance use disorders). In addition, due to reports of taste and smell loss from individuals affected by COVID-19, our lab began investigating chemosensation and COVID-19. We are focused on understanding the effects of the SARS-CoV-2

Features work related to taste and smell alterations often not discussed in nursing and health professional studies Offers examples of measures and protocols that can be applied clinically Links the work done in basic research to clinical practice in sensory biology and associated conditions