Inflammation, Infection, and Microbiome in Cancers, 1st ed. 2021 Evidence, Mechanisms, and Implications Physiology in Health and Disease Series

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers.

Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes.

This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

Dr. Jun Sun is a tenured Professor of Medicine at the University of Illinois at Chicago (UIC), U.S.A.. She is an elected fellow of American Gastroenterological Association (AGA) and American Physiological Society (APS). She chairs the AGA microbiome section. Her research interests are host-microbiome interactions in inflammation and cancer. Her key achievements include 1) characterization of vitamin D receptor regulation of intestinal barrier and microbiome in inflammation and cancer, 2) identification of dysbiosis and intestinal dysfunction in amyotrophic lateral sclerosis (ALS), 3) characterization of bacteria in regulating intestinal stem cells and leading to cancer, and 4) identification and characterization of the Salmonella protein AvrA in host-bacterial interactions. Dr. Sun has published over 190 scientific articles in peer-reviewed journals, including Gut, Gastroenterolog, Cell Stem Cells, Nature Genetics, JBC, Autophagy, AmericanJournal of Pathology, & American Journal of Physiology-GI.  She is the leading editor of 4 books on microbiome, including a Nature/Spring book entitled “Mechanisms underlying host-microbiome interactions in pathophysiology of human diseases.”  This book has shown a novel theme and multiple disciplinary topics of microbiome research for a broad audience. She is the author of Nature/Spring book “Statistical Analysis of Microbiome Data with R. This timely book addresses the statistical modelling and analysis of microbiome data using cutting-edge R software. She serves on the editorial board of more than 10 peer-reviewed international scientific journals. She services study sections for the NIH, American Cancer Society, and other national and international research foundations. She has been invited to chair meetings on microbiome, be a keynote speaker, and to write reviews, editorials, and comments on microbiome in human diseases published forp

Highlights connections between infection, inflammation and various cancers Offers insights into the progress of immune therapy and stem cell research in cancer Discusses emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy