Infection and Cancer: Bi-Directorial Interactions, 1st ed. 2015

This unique book summarizes current knowledge on co-development of infectious diseases and cancer. It provides an overview of the complex and unique role of the immune system, inflammation, tumor-mediated immunosuppression and infection-induced immunomodulation in cancer and infection progression.

Chapters are organized into themed parts, beginning with a look at the historical perspective of human tumor viruses, then aspects and examples of infection-related cancers and cancer-associated infections. The work discusses how cancer- and infection-associated immune responses interact in a bi-directorial fashion and how these interactions may evolve during both disease progression and in response to therapy. The phenomenon of independent development of cancer and infection in the same host, known as comorbid cancer-infection progression, is explored.

Understanding the complex pathways involved in the progression of infection and cancer will allow the prevention of the development of certain types of cancer, as well as advancing prophylactic anti-cancer vaccines. Readers of this work will discover innovative approaches for multidisciplinary projects, focusing on the design of original therapeutic modalities for cancer therapy. The book will therefore be particularly valuable to scholars interested in cancer immunology and researchers and clinicians in the field of basic and applied immunobiology and microbiology.

Infection and Cancer: Multi-directorial relationship
Michael R. Shurin, Jinbao Zong, Anton A. Keskinov 

Part I  Infection-associated cancers 

Human tumor viruses: A historical perspective
Joseph S. Pagano 

Epidemiology of virus infection and human cancer
Jessica Liu, Hwai-I Yang, Mei-Hsuan Lee, Wan-Lun Hsu, Hui-Chi Chen, Chien-Jen Chen 

Bacterial infections and cancer development
Marianna Agassandian and Galina V. Shurin 

Human protozoal infections and their potential for causing neoplasms
Raavi Gupta, Maja Nowakowski, M.A. Haseeb 

An update on helminths in human carcinogenesis
Aditya Reddy and Bernard Fried 

Infection-associated hematological malignancies
Dmitriy W. Gutkin 

Multiple infections and cancer: Etiology, mechanisms and implications in cancer control
Verma Mukesh 

Inflammatory mechanisms of infection-associated cancer
Jotham Suez, Maayan Levy, Christoph A. Thaiss, Eran Elinav 

Part II  Infection-associated cancers:Specific examples  

Oral infection, carcinogenesis and cancer
Jukka H. Meurman and Antonio Bascones-Martinez 

Streptococcus Bovis and colorectal cancer
Salvatore Galdy 

Human papillomavirus-related cancers
Antonio Carlos de Freitas, Ana Pavla Almeida Diniz Gurgel, Bárbara Simas Chagas, Carolina Medeiros do Amaral, Eliane Campos Coimbra, Elyda Gonçalves de Lima, Jacinto da Costa Silva Neto, Maria da Conceição Gomes Leitão, Rita de Cássia Pereira de Lima 

Part III           Cancer-associated infections 

Infectious diseases in cancer patients: An overview
Tatiana Zorina and Alexis Styche 

Part IV           Infection and cancer: Comorbid development  

Comorbid development of infection and cancer
Nahed Ismail, Michael R. Shurin, Abdulrahman Zaghloul 

Part V             Infection agent-based vectors for cancer therapy  

Bacterial cancer therapy: how patients might benefit from Salmonella infectionsPaulina Chorobik, Dominik Czaplicki, Karolina Ossysek, Joanna Bereta 

Development of Salmonella-based cancer vaccines
Xin Xu, Michael Hensel, Leonid S. Metelitsa 

Harnessing the host immune response to infection - BCG immunotherapy for bladder cancer
Hana Zdimerova,Matthew L. Albert, Molly A. Ingersoll

Index

Summarizes current knowledge on co-development of infectious diseases and cancer

Supports understanding of pathways involved in the progression of infection and cancer

Presents both experimental animal results and human clinical data