Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases
Auteur : Gupta Anil
2. Role of Caspases, Apoptosis and Additional Factors in Pathology of Alzheimer’s disease
3. Role of Caspases and Apoptosis in Parkinson’s disease
4. Illustrated Etiopathogenesis of Huntington’s Disease
- Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aß peptide, tau protein, a-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases
- Elucidates neurogenetics of gene APP, gene PSEN1, gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases
- Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer’s disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial a 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors
- Demonstrates the role of caspases and apoptosis in Parkinson’s disease covering truncation of a-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, ?tau314, and several other factors
- Explains etiopathogenesis of Huntington’s disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1a gene, advanced glycation end-products, autophagy, and many other significant topics
Date de parution : 12-2021
Ouvrage de 242 p.
19x23.4 cm
Thème de Human Caspases and Neuronal Apoptosis in... :
Mots-clés :
neurodegenerative diseases; apoptosis; neurodegenerative diseases; oxidative stress; impaired mitochondrial enzymes; gene mutation; a-Synuclein protein in Parkinson disease; Aß peptide in alzheimer disease; Alzheimer diseases; Gene LRRK2 in parkinson disease; Genetics in late-onset alzheimer disease; Huntingtons's diseases; Impaired mitochondrial dynamics in neurodegenerative diseases; Mitochondrial abnormalities in neurodegenerative diseases; Mutations in APP gene in neurodegenerative diseases; Parkinson's disease; PSEN1gene in neurodegenerative diseases; Transition metals in neurodegenerative diseases; Ubiquitin proteasome system in neurodegenerative diseases