Mitochondrial Dynamics and Neurodegeneration, 2011

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer?s, Parkinson?s, and Huntington?s diseases.

Comprehensive reviews written by leading researchers in the field Numerous color figures and illustration to help the readers to better grasp the topics A chapter on mitophagy, one of the most intensely studied topics in neurodegenerative diseases research Includes supplementary material: sn.pub/extras