Contemporary Topics in Immunobiology, Softcover reprint of the original 1st ed. 1974 Volume 3

Contemporary immunobiology is an ever-diversifying field that embraces many aspects of cellular and humoral immune responsiveness. This includes the phylogeny, ontogeny, induction, regulation, expression, and differentiation of the immune-cell series, as well as the relationship of these to the pathogenesis of many disease processes. It is clearly beyond the limitations of each volume in this series to comprehensively cover progress in each of these fields. Three general areas of contemporary investigations are discussed in the current issue: cellular events of B cell differentiation, including antigen recognition and respon­ siveness of B lymphocytes; regulation of the immune response by T cells, and the roles of this regulatory system in allotype suppression and in autoimm unity; and the genetic control of immune responses and its possible relation to disease pathogenesis. Analysis of responsiveness of B lymphocytes has been greatly aided by the availability of athymic nude mice. The immunological responsiveness of these mice to a wide range of stimuli has been reviewed and analyzed by H. H. Wortis. This article concludes with the provocative thesis that in the future "nudes will supply new rather than confirmatory data . . . (especially regarding) the develop­ ment of neoplasia. " In contrast to the studies on the congenitally athymic mice, G. F.

1. T Cell Control of Antibody Production.- Evidence for a Suppressor Effect of T Cells.- Suppressor Macrophages.- Suppressor Animals.- Interactions Between T Cell Subpopulations.- Subclasses of B Cells.- Meaning of “Thymus Independency”.- T Cell Discrimination of Signals.- Do Tolerant Cells Exist?.- Meaning in Life.- Possible Models.- Summary.- Abbreviations.- Acknowledgments.- References.- 2. Short-Term and Chronic Allotype Suppression in Mice.- Short-Term Allotype Suppression.- Chronic Allotype Suppression.- Mechanism of Chronic Allotype Suppression.- Acknowledgments.- References.- 3. On the Relationship Between Cellular and Humoral Antibodies.- Cellular and Humoral Antibodies Produced by B Cells.- Cellular and Humoral Antibodies Produced by T Cells.- Acknowledgments.- References.- 4. T Cell Modification of B Cell Responses to Antigen in Mice.- Experimental T Cell Deficiencies.- “T Cell Independent” Responses of B Cells.- Conclusions.- Abbreviations.- Acknowledgments.- References.- 5. Genetic Control of Antibody Responses to Myeloma Proteins of Mice.- Immunoglobulin Allotypes of the Mouse.- Genetic Control of the Immune Response to BALB/c IgA Myeloma Proteins.- Genetic Control of the Immune Response to BALB/c IgG Myeloma Proteins.- Genetic Control of the Immune Response to BALB/c IgH (?2 b) Myeloma Proteins.- Mapping of Ir Genes in the H-2 Complex.- Function of Ir Gene Products.- Acknowledgment.- References.- 6. Histocompatibility Systems, Immune Response, and Disease in Man.- HL-A and H-2.- H-2 and Murine Leukemia.- Immune Response Genes.- HL-A and Disease.- Leukemias.- Lymphomas.- Immunopathic Diseases.- Genetic Diseases.- Cancer (Other than Lymphomas).- Infectious Diseases.- HL-A and Immune Responses.- Nature of Association Between HL-A and Disease.-References.- 7. Antigen-Binding Receptors on Lymphocytes.- Methods for Measuring ABC.- ABC in Nonimmune Animals.- ABC in Immune Animals.- ABC in Tolerance.- Summary.- References.- 8. Modification of B Lymphocyte Differentiation by Anti-immunoglobulins.- Suppression of First Stage B Lymphocyte Differentiation: In Vivo Models.- Suppression of Second Stage Differentiation by Anti-Immunoglobulins: In Vitro Models.- Conclusion.- Acknowledgments.- References.- 9. The Roles of T and B Lymphocytes in Self-Tolerance and Autoimmunity.- Tolerance in T and B Lymphocytes.- T Cell Helper Effects in Immune Responses.- Autoantigen-Binding Lymphocytes in Normal Subjects.- Allogeneic Cell Stimulation, Adjuvants, and Autoantibody Formation.- Control of Immune Responses by T Cells.- Congenital Virus Infections.- General Comment.- References.- 10. Immunological Studies of Nude Mice.- Genetics.- Cellular Defects.- Response to Mitogens.- Mitogenic Response to Allogeneic Cells.- Mitogenic Responses to Antigens.- Antigen Binding.- Immunoglobulin Levels.- Response to Thymus Independent Antigens.- Response to Thymus Dependent Antigen.- Contact Sensitivity.- Cell Mediated Cytotoxicity.- Skin Grafts.- Tumor Grafts.- Spontaneous Tumors.- Effect of Mitogens on Antibody Production In Vitro.- Effect of Thymocytes and Thymus-Derived Cells on Antibody Production In Vitro.- Thymus Grafts In Vivo.- Comments.- Acknowledgments.- References.