Carnitine Metabolism and Human Nutrition

Carnitine Metabolism and Human Nutrition offers a contemporary and in-depth look at the biological effects of carnitine metabolism and its application to clinical and sports nutrition, based on decades of robust scientific enquiry. It gathers and distills key results of the last 20 years of carnitine research to provide an invaluable reference tool for students, researchers, and clinicians.

This book addresses the importance of carnitine in skeletal muscle fuel metabolism, the complexities and importance of muscle carnitine transport, and the metabolic insight that has been gained from experiments manipulating muscle carnitine stores. The authors cover the potential application of carnitine supplementation in specific clinical populations and the role of carnitine as an ergogenic aid for athletes. They also provide a comprehensive mechanistic overview of skeletal muscle insulin resistance, including the role of carnitine shuttle systems in the metabolic abnormalities associated with obesity and the metabolic syndrome.

Carnitine Metabolism and Human Nutrition provides you with a comprehensive and up-to-date look at the properties and underlying metabolic biochemistry of carnitine. The book provides contributions from leading international scientists, each a pioneer in their chosen study of carnitine metabolism or its application to human nutrition.

Section I: Carnitine homeostasis and tissue metabolism.. Carnitine homeostasis in humans. Carnitine and energy metabolism. Section II: Carnitine transport and metabolism in skeletal muscle.. The role of carnitine in the integration of skeletal muscle fuel metabolism. Skeletal muscle carnitine transport. The metabolic impact of manipulating the muscle carnitine pool. Section III: Applications of carnitine in human nutrition. Carnitine metabolism and nutrition in dialysis patients. Carnitine metabolism and nutrition in insulin resistance and type 2 diabetes. Carnitine metabolism and nutrition in peripheral vascular disease. Carnitine as an ergogenic aid for sports performance. Conclusions and future directions. Carnitine metabolism and nutrition in insulin resistance and type 2 diabetes. Carnitine metabolism and nutrition in peripheral vascular disease. Carnitine as an ergogenic aid for sports performance. Conclusions and future directions.