Delta Opioid Receptor Pharmacology and Therapeutic Applications, 1st ed. 2018 Handbook of Experimental Pharmacology Series, Vol. 247

This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson?s disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Part 1. DOPR Ligands.- 1. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept.- 2. Multifunctional Opioid Ligands.- 3. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins.- Part 2. DOPR Signaling.- 4. Ligand-Directed Signaling at the Delta Opioid Receptor.- 5. Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.- 6. Evidence and Function Relevance of Native DOR–MOR Heteromers.- Part 3. DOPR and Disease.- 8. The Delta Opioid Receptor in Pain Control.- 9. Delta Opioid Receptors and Modulation of Mood and Emotion.- 10. Delta Opioid Pharmacology in Relation to Alcohol Behaviors.- 11. Delta Opioid Receptors: Learning and Motivation.- 12. Delta Opioid Pharmacology in Parkinson’s Disease.- 13. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders.- 14. Delta Opioid Receptors and Cardioprotection.- 15. The Roles of Opioid Receptors in Cutaneous Wound Healing.