Multiresidue Methods for the Analysis of Pesticide Residues in Food Food Analysis & Properties Series

In the last decades the public concern on the pesticide residues content in foods have been steadily rising. The global development of food trade implies that aliments from everywhere in the world can reach the consumer`s table. Therefore, the identification of agricultural practices that employ different pesticides combinations and application rates to protect produce must be characterized, as they left residues that could be noxious to human health. However, the possible number of pesticides (and its metabolites of toxicological relevance) to be found in a specific commodity is almost 1500, and the time needed to analyze them one by one, makes this analytical strategy a unrealistic task. To overcome this problem, the concept of Multi Residue Methods (MRM) for the analysis of pesticide traces have been developed. The advent of new and highly sensitive instrumentation, based in hyphenatedchromatographic systems to coupled mass analyzers (XC (MS/MS) or MSn) permitted simultaneously the identification and the determination of up to hundreds of pesticide residues in a single chromatographic run. Multiresidue Methods for the Analysis of Pesticide Residues in Foodpresents the analytical procedures developed in the literature, as well as those currently employed in the most advanced laboratories that perform routinely Pesticide Residue Analysis in foods. In addition to these points, the regulations, guidelines and recommendations from the most important regulatory agencies of the world on the topic will be commented and contrasted.

Regulatory Issues. Regulatory Issues (Sanco Document, Epa, Codex and Eurachem Guidelines). Sample Preparation. Most Common Sample Preparation Methods for Mrm (Mini Luke, Acoet, Mspd). Other Sample Preparation Methods for Mrm (Ase, Spme, Dlle, Scfe, Etc). Quechers Approaches. Analysis. Pesticide Physicochemical Properties and Chromatographic Analysis. Modern Mass Spectrometric Configurations for Pesticide Residue Analysis. Gc-Ms Coupling - Gc/Ms Single Quad - Gc/Ms (Itd) - Gc (Ms/Ms) - Gcxgc (Ms) (Tof). Lc-Ms Coupling - Lc-Ms/Ms Triple Quad, Qtrap, Orbitrap, Q-Tof - Lcxlc (Ms/Ms). Gas Chromatographic Analysis - Conventional Detectors (Ecd, Npd, Fpd) - Selected Applications of Gc-Ms and Gc-Ms/Ms. Liquid Chromatography - Selected Applications of Lc-Ms and Lc- Ms/Ms. Targeted Analysis Vs. Untargeted Analysis. Matrix Effects in Gc and Lc. Mrm for Pesticide Residues in Fruits, Vegetables and Cereals. Mrm for Pesticide Residues in Animal Products. Mrm for Pesticide Residues in the Environment. Data Bases for Pesticide Residue Analysis. Conclusions. Conclusions.

Horacio Heinzen is a chemist of pharmacognosy (UdelaR, 1983) and earned his degree of Doctor of Göttingen University, Germany, in 1993. He is professor of pharmacognosy and natural products chemistry faculty, UdelaR, since 1998.His main lines of research are the characterization of new bioactive compounds, the validation of the action of native medicinal plants, and the development of a new herbal. In the analytical area, he turned to the area of analysis of pesticide residues and organic contaminants. In particular, his works focus on the development of new analytical meth-odologies on the preparation of samples for the analysis of trace organic compounds in complex matrices, both food and pharmaceutical raw materials.He  is  coauthor  of  more  than  70  original  papers  in  scientific  magazines.  He wrote many book chapters and he was a speaker at numerous conferences, national, regional, and international.He  was  president  of  the  Latin  American  Society  of  Phytochemistry  (2005–2008)  and he is a member of the International Union of Pure and Applied Chemistry and the Scientific Committee of the Latin American  Pesticide  Residue  Workshop  (LAPRW)  Subcommittee for Crop Protection.

Leo M.L. Nollet received his MS (1973) and PhD (1978) in biology from the Katholieke Universiteit Leuven, Belgium. He is editor and associate editor of numerous books. He edited for M. Dekker, New York—now CRC Press of Taylor & Francis—the first, sec-ond, and third editions of the books entitled Food Analysis by HPLC and Handbook of Food Analysis. The last edition is a two-volume book. He also edited the Handbook of Water  Analysis (first, second, and third editions) and Chromatographic Analysis of the Environment, Third Edition (CRC Press).With  F.  T