Tissue-Specific Cell Signaling, 1st ed. 2020

Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters.

This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors.

Preface

1.      Tissue-specific cell signaling: introduction

2.      Beyond the brain signaling

3.      Cell signaling within pituitary, the master gland of the endocrine system

4.      Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands

5.      Signaling pathways governing activation of innate immune cells

7.      Signaling pathways involved in kidney and urinary tract physiology and pathology

8.      More than androgens: hormonal and paracrine signaling in prostate development and homeostasis

9.      Testicular signaling: team work in sperm production

10.  Sperm signaling specificity: from sperm maturation until oocyte recognition

11.  Hormone signaling pathways in the postnatal mammary gland

12.  Oogenesis signaling: from development to environmental plasticity and aging

13.  Key signaling pathways in the cardiovascular system

14.  Growth factor signaling in the maintenance of adult lung homeostasis

15.  The signaling pathways involved in the regulation of skeletal muscle plasticity

16.  Adipocyte-specific signaling

Joana Vieira Silva; Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine – iBiMED, University of Aveiro, Portugal; Institute for Innovation and Health Research (i3S), University of Porto, Portugal; Department of Microscopy, Laboratory of Cell Biology, and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal; joanavieirasilva@ua.pt

Maria João Freitas; Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium; mariajoao.freitas@kuleuven.be

Margarida Fardilha; Laboratory of Signal Transduction, Institute for research in Biomedicine- iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal; mfardilha@ua.pt

First textbook to cover cell-specific signaling of over 20 cell-types by experts in the field

Covers topics from ligand/receptor interaction to organ/organism response

Tabular and well-illustrated, will be extremely valuable in the understanding of this complex field