Biology of the Lysosome, 1996 Subcellular Biochemistry Series, Vol. 27

Delivery Routes to the Lysosome. The Taxonomy of Lysosomes and Related Structures, J.B. Lloyd. Origin of Lysosomal Proteins, T. Braulke. Endocytosis, E. Smythe. Autophagy, E.G. Mortimore, et al. Selective Proteolysis: 70kD Heat Shock Protein and Ubiquitin-Dependent Mechanisms, R.J. Mayer, F.J. Doherty. Metabolism in the Lysosome. Lysosomal Metabolism of Proteins, R.W. Mason. Lysosomal Metabolism of Glycoconjugates, B.G. Winchester. Lysosomal Metabolism of Lipids, W.J. Johnson, et al. Lysosomal Nucleic Acid and Phosphate Metabolism, and Related Metabolic Reactions, R.L. Pisoni. The Lysosome in Its Cytoplasmic Environment. Acidification of Lysosomes and Endosomes, R.W. Van Dyke. Metabolite Efflux and Influx Across the Lysosome Membrane, J.B. Lloyd. Lysosome Pharmacology and Toxicology, R. Wattiaux, S. Wattiaux-De Coninck. Index.

I: Delivery Routes to the Lysosome.- 1 The Taxonomy of Lysosomes and Related Structures.- 2 Origin of Lysosomal Proteins.- 3 Endocytosis.- 4 Autophagy.- 5 Selective Proteolysis: 70-kDa Heat-Shock Protein and Ubiquitin-Dependent Mechanisms?.- II: Metabolism in the Lysosome.- 6 Lysosomal Metabolism of Proteins.- 7 Lysosomal Metabolism of Glycoconjugates.- 8 Lysosomal Metabolism of Lipids.- 9 Lysosomal Nucleic Acid and Phosphate Metabolism and Related Metabolic Reactions.- III: The Lysosome in Its Cytoplasmic Environment.- 10 Acidification of Lysosomes and Endosomes.- 11 Metabolite Efflux and Influx across the Lysosome Membrane.- 12 Lysosome Pharmacology and Toxicology.