Inflammasome Signaling and Bacterial Infections, Softcover reprint of the original 1st ed. 2016 Current Topics in Microbiology and Immunology Series, Vol. 397

This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.

Presents a comprehensive collection of reviews on the multiple facets of inflammasome signal transduction

Discusses the latest insights into the major components of known canonical and non-canonical inflammasome complexes

Offers a valuable resource both for readers new to the field and for professionals already working in the area of inflammasomes

Includes supplementary material: sn.pub/extras