Comprehensive Virology, Softcover reprint of the original 1st ed. 1980 Vol. 16: Virus-Host Interactions: Viral Invasion, Persistence, and Disease Comprehensive Virology Series, Vol. 16

The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num­ bering, has probably reached that stage at which relatively few new­ truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua­ ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.

1 Viral Invasion: Morphological, Biochemical, and Biophysical Aspects.- 1. Introduction.- 2. Methods.- 3. Invasion of Cells by Naked Viruses.- 4. Erythrocyte Membrane Structure in Relation to Viral Hemagglutination.- 5. Invasion of Cells by Enveloped Virus.- 6. Summary and Conclusion.- 7. References.- 2 Viral Persistence: Evolution of Viral Populations.- 1. Introduction.- 2. Evolution of Virus in Persistence of RNA Viruses.- 3. Evolution of Virus in Persistence of DNA Viruses.- 4. Patterns of Evolution of Virus Properties in Persistent Infection.- 5. References.- 3 Defective Interfering RNA Viruses and the Host-Cell Response.- 1. Introduction.- 2. Structure and Genome Arrangement of DI Particles.- 3. Mechanisms of DI-Particle Generation, Replication, and Interference.- 4. Role of DI Particles in Long-Term Viral Persistence.- 5. Recent Preliminary Evidence for DI-Particle Involvement in Persistence of DNA Viruses.- 6. Conclusion.- 7. References.- 4 Persistence and Transmission of Cytomegalovirus.- 1. Introduction.- 2. Physical, Morphological, and Molecular Characteristics.- 3. Detection of Cytomegalovirus Infections.- 4. Clinical Disease.- 5. Latency and Persistence.- 6. Transmission.- 7. In Vitro Transformation of Mammalian Cells.- 8. Association of Cytomegalovirus with Cancer in Humans.- 9. Vaccines and Antiviral Agents.- 10. Looking Ahead.- 11. References.- 5 Aleutian Disease of Mink: A Model for Persistent Infection.- 1. Introduction.- 2. The Virus.- 3. The Disease Process.- 4. Immunological Aspects of Infection.- 5. Genetic Aspects.- 6. Discussion.- 7. References.- 6 Role of Viruses in Chronic Neurological Diseases.- 1. Introduction.- 2. Mechanisms of Virus Dissemination to the CNS.- 3. Mechanisms of Viral Clearance from the CNS.- 4. Mechanisms of Chronic Disease Induction.- 5. Subacute Spongiform Encephalopathies.- 6. Human Disease of Suspected Viral Etiology.- 7. Conclusions.- 8. References.- 7 Host Plant Responses to Virus Infection.- 1. Introduction.- 2. Kinds of Host Response.- 3. Influence of Host Genotype.- 4. Influence of the Viral Genome.- 5. Possible Mechanisms of Disease Induction.- 6. Organelle Responses.- 7. Cellular Responses.- 8. Plant Responses.- 9. Use of Protoplasts to Study Host Responses.- 10. References.