Analytical and Quantitative Cardiology, Softcover reprint of the original 1st ed. 1997 Advances in Experimental Medicine and Biology Series, Vol. 430

The tenth Henry Goldberg Workshop is an excellent occasion to recall our goals and celebrate some of our humble achievements. Vision and love of our fellow man are combined here to: 1) Foster interdisciplinary interaction between leading world scientists and clinical cardiologists so as to identify missing knowledge and catalyze new research ideas; 2) relate basic microscale, molecular and subcellular phenomena to the global clinically manifested cardiac performance; 3) apply conceptual modelling and quantitative analysis to better explore, describe, and understand cardiac physiology; 4) interpret available clinical data and design new revealing experiments; and 5) enhance international cooperation in the endless search for the secrets of life and their implication on cardiac pathophysiology. The first Goldberg Workshop, held in Haifa, in 1984, explored the interaction of mechanics, electrical activation, perfusion and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University, in 1986, highlighted the transformation of the microscale activation phenomena to macro scale activity and performance, relating electrophysiology, energy metabolism and cardiac mechanics. The fourth Goldberg Workshop continued the effort to elucidate the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop concentrated on the effect of the inhomogeneity of the cardiac muscle on its performance. The sixth Workshop highlighted new imaging techniques which allow insight into the local and global cardiac performance.

I. Molecular Signalling.- 1 Ca2+-Signaling in Cardiac Myocytes: Evidence from Evolutionary and Transgenic Models.- 2 Diastolic Viscoelastic Properties of Rat Cardiac Muscle; Involvement of Ca2+.- 3 The Beta Subunit, Kvß1.2, Acts as a Rapid Open Channel Blocker of NH2-Terminal Deleted Kv1.4 ?-Subunits.- 4 Signal Transduction in Ischemic Preconditioning.- 5 Ca2+ Sparks within 200 nm of the Sarcolemma of Rat Ventricular Cells: Evidence from Total Internal Reflection Fluorescence Microscopy.- 6 Uncoupling of G-Protein Coupled Receptors In Vivo: Insights from Transgenic Mice.- II. The Contractile Mechanism and Engergetics.- 7 Molecular Control of Myocardial Mechanics and Energetics: The Chemo-Mechanical Conversion.- 8 Myocardial Cell Energetics.- 9 Human Heart Failure: Determinants of Ventricular Dysfunction.- III. Cardiac Mechanics and Flow Dynamics.- 10 How Cardiac Contraction Affects the Coronary Vasculature.- 11 Dynamic Interaction between Myocardial Contraction and Coronary Flow.- 12 The Relations between Microvascular Structure and Oxygen Supply.- IV. Vascular Structure and Remodeling.- 13 Endothelial Gene Regulation by Laminar Shear Stress.- 14 3D Architecture of Myocardial Microcirculation in Intact Rat Heart: A Study with Micro-CT.- 15 Vascular Imaging by Ultrasound: 3D Reconstruction of Flow Velocity Fields for Endothelial Shear Stress Calculation.- 16 Compensatory Enlargement, Remodeling, and Restenosis.- 17 Atherosclerosis Studies by Intracoronary Ultrasound.- V. Myocardial Structure and Function.- 18 Tissue Remodeling with Micro-Structurally Based Material Laws.- 19 Multiaxial Myocardial Mechanics and Extracellular Matrix Remodeling: Mechanochemical Regulation of Cardiac Fibroblast Function.- 20 In Vivo Assessment of Regional Myocardial Work in Normal CanineHearts Using 3D Tagged MRI.- 21 Noninvasive Measurement of Cardiac Strain with MRI.- 22 Ventricular Remodeling: From Bedside to Molecule.- VI. Electrical Activation and Propagation.- 23 Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions.- 24 Modeling of Internal pH, Ion Concentration, and Bioenergetic Changes during Myocardial Ischemia.- 25 Gap Junctions: Functional Effects of Molecular Structure and Tissue Distribution.- 26 3D Cardiac Imaging of Electromechanical Coupling.- 27 Percutaneous Multielectrode Endocardial Mapping and Ablation of Ventricular Tachycardia in the Swine Model.- VII. The Cardionome: Concepts in Modeling.- 28 Design and Strategy for the Cardionome Project.- 29 Integrative and Interactive Studies of the Cardiac System: Deciphering the Cardionome.- 30 Technology vs Physiology: General Discussion Moderator.- Closure.- The Editors.- List of Contributors.