Lavoisier S.A.S.
14 rue de Provigny
94236 Cachan cedex
FRANCE

Heures d'ouverture 08h30-12h30/13h30-17h30
Tél.: +33 (0)1 47 40 67 00
Fax: +33 (0)1 47 40 67 02


Url canonique : www.lavoisier.fr/livre/sciences-de-la-vie/membrane-transporters-in-drug-discovery-et-development-methods-et-protocols-methods-in-molecular-biology-vol-637/yan/descriptif_1852693
Url courte ou permalien : www.lavoisier.fr/livre/notice.asp?ouvrage=1852693

0 article 

 Frais de port 0,01€*

Exclusivité web : à partir de 35 euros d’achat, frais de port à 1 centime pour les expéditions vers la France métropolitaine, la Suisse et l’UE avec Colissimo ou GLS

Membrane Transporters in Drug Discovery and Development, 2010 Methods and Protocols Methods in Molecular Biology Series, Vol. 637

Langue : Anglais

Coordonnateur : Yan Qing

Couverture de l’ouvrage Membrane Transporters in Drug Discovery and Development

Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.  Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology? series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.

 

Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Membrane Transporters and Drug Development: Relevance to Pharmacogenomics, Nutrigenomics, Epigenetics, and Systems Biology.- Bioinformatics for Transporter Pharmacogenomics and Systems Biology: Data Integration and Modeling with UML.- Multidrug Resistance: Phylogenetic Characterization of Superfamilies of Secondary Carriers that Include Drug Exporters.- Targeting Drug Transporters – Combining In Silico and In Vitro Approaches to Predict In Vivo.- Methods to Evaluate Transporter Activity in Cancer.- Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative RT-PCR.- Fluorescence Studies of Drug Binding and Translocation by Membrane Transporters.- A Model for Transport Studies of the Blood–Brain Barrier.- Genetic Variants in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) and Neuropsychiatric Disorders.- Equilibrium Binding and Transport by Vesicular Acetylcholine Transporter.- ABC Transporters in Ophthalmic Disease.- Imaging of Protein Translocation In Situ in Skeletal Muscle of Living Mice.- Glucose Transporters in Parasitic Protozoa.- NMR Studies of Membrane Proteins.- Site-Directed Mutagenesis in the Study of Membrane Transporters.- Xenopus laevis Oocytes.- Measurement of Intracellular pH.- Measurement of Plasma Membrane Calcium–Calmodulin-Dependent ATPase (PMCA) Activity.- Assessment of the Contribution of the Plasma Membrane Calcium ATPase, PMCA, Calcium Transporter to Synapse Function Using Patch Clamp Electrophysiology and Fast Calcium Imaging.
Cutting-edge technologies for transporter studies in drug discovery and development Transporter structure-function studies and drug treatments in various diseases Latest developments in pharmacogenomics, systems biology, and bioinformatics Step-by-step methods with tips on troubleshooting and avoiding known pitfalls Wide-ranging and practical protocols by leading researchers in the field Includes supplementary material: sn.pub/extras

Date de parution :

Ouvrage de 365 p.

17.8x25.4 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

158,24 €

Ajouter au panier

Date de parution :

Ouvrage de 365 p.

17.8x25.4 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

105,49 €

Ajouter au panier