Intrabodies, Softcover reprint of the original 1st ed. 1998 Basic Research and Clinical Gene Therapy Applications

Introduction.- Research applications.- Cancer gene therapy.- HIV-1 gene therapy.

1. Designing Intrabodies: Structural Features and the Use of Intracellular Trafficking Signals.- 2. Phage Libraries for Generation of Single Chain Fv Antibodies for Intracellular Immunization.- 3. Phenotypic Knockout of the Human Interleukin-2 Receptor ? Chain On Primary and HTLV-I Transformed T Cells.- 4. Intracellular Antibodies as Tools to Study ErbB Receptor Tyrosine Kinases.- 5. Neuroantibodies: The Use of Recombinant Antibody Expression in the Central Nervous System.- 6. Intracellular Antibody-Mediated Knockout of the ErbB-2 Oncoprotein as a Cancer Gene Therapy Approach.- 7. Intracellular Targeting of Oncogenes: A Novel Approach for Cancer Therapy.- 8. Intrabodies Against the HIV-1 Regulatory Proteins: Tat and Rev as Targets for Gene Therapy.- 9. Gene Therapy for HIV-1 Using Intracellular Antibodies Against HIV-1 Gag Proteins.- 10. Single Chain Variable Fragment-Based Strategies for Anti-HIV-1 Gene Therapy: Targeting the Viral Preintegration Complex and Combination Molecular Approaches.

State-of-the-art resource for gene therapists and all researchers interested in using intrabodies in gene therapy