Biointeractions of Nanomaterials

An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues.

Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials.

These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.

Introduction: Biointeractions of Nanomaterials: Challenges and Solutions. Nanoparticles Exposure in Occupational Environment. Physicochemical Characterization Dependent Toxicity of Nanoparticles. Cytotoxicity of Stimuli-responsive Nanomaterials: Predicting Clinical Viability through Robust Biocompatibility Profiles. Biosensing Devices for Toxicity Assessment of Nanomaterials. Carbon Nanotubes and Pulmonary Toxicity. Nanotoxicity of Polymeric and Solid Lipid Nanoparticles.Analytical Characterization of Nanomaterials in Biological Matrices for Hazard Assessment. Nanoparticles and Human Health: A Review of Epidemiological Studies. Toxicogenomic Approach to Understand Toxicity of Nanoparticles. Nanomaterial Based Gene and Drug Delivery: Pulmonary Toxicity Considerations. Cardiovascular Toxicity of Nanomaterials. Toxicity of Nanomaterials on Gastrointestinal Tract. Toxicity of Nanomaterials on Liver, Kidney and Spleen.The Regulatory Implications of Nanotechnology. Ocular Toxicity of Nanoparticles.Genotoxicity of Nanoparticles.Interactions of Polysaccharide-Coated Nanoparticles with Proteins. Models for Risk Assessments of Nanoparticles.Immuno-Toxicity of Carbon Nanoparticles. Index.