How to read a: the basics of evidence-based medicine (paperback)

How to Read a Paper describes the different types of clinical research reporting, and explains how to critically appraise the publications. The book provides the tools to find and evaluate the literature, and implement the findings in an evidence-based, patient-centered way. Written for anyone in the health care professions who has little or no knowledge of evidence-based medicine, it provides a clear understanding of the concepts and how to put them into practice at the basic, clinical level. Changes for the 4 th edition The fourth edition will include two new chapters on important developments in health care research and delivery, but otherwise retains its original style, size, and scope. New chapter on quality improvement describing papers on quality improvement projects using ebm methods, this will extend the readership to non clinical health care professionals working in hospitals and family practice, and to nurse specialists and practice nurses working in this field New chapter on complex interventions - how to set up research projects involving both qualitative and quantitative methodology (known as mixed methods) Thorough revision and updating of existing chapters and references New illustrations diagrammatic representations of ebm concepts

Foreword to the First Edition by Professor Sir David Weatherall.

Preface to the First Edition: do you need to read this book?

Preface to the Fourth Edition.

Acknowledgements.

1 Why read papers at all?

1.1 Does "evidence-based medicine" simply mean "reading papers in medical journals"?

1.2 Why do people sometimes groan when you mention EBM?

1.3 Before you start: formulate the problem.

2 Searching the literature.

2.1 What are you looking for?

2.2 Levels upon levels of evidence.

2.3 Synthesised sources: systems, summaries and syntheses.

2.4 Pre-appraised sources: synopses of systematic reviews and primary studies.

2.5 Specialised resources.

2.6 Primary studies - tackling the jungle.

2.7 One-stop shopping: federated search engines.

2.8 Asking for help and asking around.

3 Getting your bearings - what is this paper about?

3.1 The science of "trashing" papers.

3.2 Three preliminary questions to get your bearings.

3.3 Randomised controlled trials.

3.4 Cohort studies.

3.5 Case-control studies.

3.6 Cross-sectional surveys.

3.7 Case reports.

3.8 The traditional hierarchy of evidence.

3.9 A note on ethical considerations.

4 Assessing methodological quality.

4.1 Was the study original?

4.2 Whom is the study about?

4.3 Was the design of the study sensible?

4.4 Was systematic bias avoided or minimised?

4.5 Was assessment "blind"?

4.6 Were preliminary statistical questions addressed?

4.7 Summing up.

5 Statistics for the non-statistician.

5.1 How can non-statisticians evaluate statistical tests?

5.2 Have the authors set the scene correctly?

5.3 Paired data, tails, and outliers.

5.4 Correlation, regression and causation.

5.5 Probability and confidence.

5.6 The bottom line.

5.7 Summary.

6 Papers that report trials of drug treatments and other simple interventions.

6.1 'Evidence' and marketing.

6.2 Making decisions about therapy.

6.3 Surrogate endpoints.

6.4 What information to expect in a paper describing an RCT: the CONSORT statement.

6.5 Getting worthwhile evidence out of a pharmaceutical representative.

7 Papers that report trials of complex interventions.

7.1 Complex interventions.

7.2 Ten questions to ask about a paper describing a complex intervention.

8 Papers that report diagnostic or screening tests.

8.1 Ten men in the dock.

8.2 Validating diagnostic tests against a gold standard.

8.3 Ten questions to ask about a paper that claims to validate a diagnostic or screening test.

8.4 Likelihood ratios.

8.5 Clinical prediction rules.

9 Papers that summarise other papers (systematic reviews and meta-analyses).

9.1 When is a review systematic?

9.2 Evaluating systematic reviews.

9.3 Meta-analysis for the non-statistician.

9.4 Explaining heterogeneity.

9.5 New approaches to systematic review.

10 Papers that tell you what to do (guidelines).

10.1 The great guidelines debate.

10.2 How can we help ensure that evidence-based guidelines are followed?

10.3 Ten questions to ask about a clinical guideline.

11 Papers that tell you what things cost (economic analyses).

11.1 What is an...