A Concise Guide to Clinical Trials (2^nd Ed.)

Design and execute life-saving trials with this accessible resource

Clinical trials have revolutionized the treatment of disease and the development of life-saving pharmaceuticals. They contribute decisively to diagnosis, the avoidance of early death, medical intervention and are central to the modern work of pharmaceutical producers. The design and execution of clinical trials is one of the fastest-growing and most important areas of medical and pharmaceutical research.

A Concise Guide to Clinical Trials provides an accessible and comprehensive survey of clinical trials, their design, and their applications. Beginning with a taxonomy of trial types, the book overviews stages of analysis, ethical and legal requirements, and more. Now fully updated to reflect the latest research and clinical practice, it continues to be an indispensable resource for researchers and clinicians.

Readers of the second edition of A Concise Guide to Clinical Trials will also find:

• New material on pharmaceutical trials, adaptive designs, and the use of ?big data?
• The easy-to-use organization facilitates both first-time learning and reference
• Detailed treatment of concepts such as health technology assessments (HTA), patient and public involvement and engagement (PPIE), and more

A Concise Guide to Clinical Trials is ideal for clinicians and healthcare professionals looking for a working knowledge of clinical trials, as well as for pharmaceutical workers and regulators looking to understand this vital aspect of the industry.

Foreword, v

Preface, vii

1 Fundamental concepts

2 Types of outcome measures and understanding them

3 Phase I trials

4 Phase II trials

5 Phase III trials: design

6 Phase III trials: fundamental aspects of analysis and interpretation

7 Randomised trials: additional aspects of analysis and interpretation

8 Commercial trials of medicinal products; other types of interventions; health economic analysis

9 Systematic reviews, meta-analyses, and real world evidence

10 Conducting and reporting trials

Further Reading list

Index

Allan Hackshaw is Professor of Epidemiology and Medical Statistics and Deputy Director, CRUK Cancer Trials Centre, University College London, United Kingdom.