The Duration and Safety of Osteoporosis Treatment, 1st ed. 2016 Anabolic and Antiresorptive Therapy

Providing a comprehensive review of short-and long-term adverse events of both antiresorptive and anabolic drugs, this practical guide updates the clinician on the pathophysiology of osteoporosis and the principles behind our present and future pharmaceuticals. Leading practitioners in the field examine all current literature and data regarding the duration and safety of these therapies, with recommendations for clinicians on decision-making and best practices for osteoporosis patients. An overview of the pathophysiology and epidemiology of osteoporosis and discussion of both anabolic and antiresorptive drugs is followed by fracture risk assessment and an examination of treatment failures. Next, a number of chapters are dedicated to the diagnosis, presentation and management of atypical femur fractures and osteonecrosis of the jaw (ONJ), each of which are significant patient concerns when using these osteoporosis treatments. The introduction and utilization of drug holidays is alsodiscussed, as well as the long-term outlook for management of osteoporotic patients. Written and edited by experts in the field, The Duration and Safety of Osteoporosis Treatment is a balanced resource for researchers, practitioners and policy-makers alike for clinical decision-making and patient care. 

Foreword.- Preface.- Osteoporosis: Pathophysiology & Epidemiology.- Antiresorptives.- Anabolics.- Tools for Assessing Fracture Risk and for Treatment Monitoring.- Treatment Failure.- Epidemiology of Atypical Subtrochanteric and Femoral Shaft Fractures.- Bisphosphonate-Related Atypical Femoral Fractures and Their Radiographic Features.- Factors Contributing to Atypical Femoral Fractures.- Clinical Presentation of Atypical Femur Fractures.- Effects of Antiresorptive Therapy on Bone Microarchitecture.- Management of Atypical Femoral Fractures.- Osteonecrosis of the Jaw: Clinico-Pathologic and Radiologic Features.- Epidemiology of Osteonecrosis of the Jaws from Antiresorptive Treatment.- Management of Osteonecrosis of the Jaw in Patients Receiving Antiresorptive Treatment.- Long-Term Efficacy and Safety of Treatments for Osteoporosis.- Management of Drug Holidays.- Patients Who Do Not Take Their Osteoporosis Medications:  Can We Help Them Become Compliant?.- Fractures andHealing on Antiresorptive Therapy.- Antiresorptive Therapy and Mortality and Cancer Incidence.- Other Safety Concerns.- The Impact of Regulatory and Scientific Organizations Recommendations on Clinical Decision Making.- Integrated Clinical View on Long-Term Management of Patients with Osteoporosis.- Conclusions.

Stuart L. Silverman, MD, FACP, FACR

Cedars-Sinai Medical Center

Division of Rheumatology

Department of Medicine

Los Angeles, CA, USA

University of California Los Angeles

David Geffen School of Medicine

Los Angeles, CA, USA

Bo Abrahamsen, MD, PhD

University of Southern Denmark

Odense Patient Data Explorative Network

Institute of Clinical Research

Odense, Denmark

Holbæk Hospital

Department of Medicine
Holbæk, Denmark