Progressive neuroblastoma Innovation and Novel Therapeutic Strategies Pediatric and Adolescent Medicine Series, Vol. Vol. 20
Neuroblastoma is a tumor derived from the sympathetic nervous system.
It is the most common extracranial solid tumor occurring in children and
exhibits a marked variability in outcome when the disease is categorized
by clinical (e.g. age or stage) and biologic characteristics. This book gives
an introduction into the clinical features of progressive neuroblastoma
and focuses on molecular-targeted therapies and immunotherapies of
this disease.
It has become increasingly clear that MYCN (v-myc avian myelocytomatosis
viral oncogene neuroblastoma derived homolog) holds a key position
in neuroblastic transformation and gene expression in normal and
transformed cells. In the 14 chapters important topics such as genomic
alterations in neuroblastoma and strategies for indirect molecular targeting
of MYCN are discussed. Two chapters, for example, review apoptotic
pathways and proapoptotic molecular targets in neuroblastoma, one
focusing on the p53 pathway and the other on the extrinsic and intrinsic
pathways of apoptosis. Other chapters cover topics related to immunology
in neuroblastoma, such as immune regulation in neuroblastoma,
immunotherapy related to passive and active vaccination approaches
and additional immunotherapy in the treatment of progressive disease.
This volume is essential reading for all clinicians and basic researchers
who are involved in delivering health care to patients with progressive
neuroblastoma.
Preface: Christiansen, H.; Christiansen, N.M.
Clinical Introduction
• Clinical Features of Progressive Neuroblastoma: Simon, T.
Genomic Alterations
• DNA Copy Number Changes and Beyond: Fieuw, A.; Schulte, J.H.; De Preter, K.; Speleman, F.
• Genomic Alterations and Abnormal Cell Cycle in High-Risk Neuroblastoma: Capasso, M.; Sidarovich, V.; Quattrone, A.; Tonini, G.P.
Targeting MYCN
• MYCN and MicroRNAs: Althoff, K.; Schulte, J.H.
• MYCN and Its Posttranslational Regulation in Neuroblastoma: Otto, T.
Apoptosis and Angioneogenesis
• Neuroblastoma and the p53 Pathway: Chen, L.; Tweddle, D.A.
• Targeting Cell Death Pathways in Neuroblastoma: Fulda, S.
• Neuroblastoma and Angiogenesis: Rössler, J.
Molecular-Targeted Therapy Studies
• The Role of the Anaplastic Lymphoma Kinase Receptor in Neuroblastoma: Yeung, C.M.; George, R.E.
• Molecular-Targeted Therapy in Refractory or Relapsed Neuroblastoma: Corbacioglu, S.
Immunology
• Immune Regulation in Neuroblastoma: Fest, S.; Starke, S.
• Approaches to Passive and Active Vaccination against Neuroblastoma: Lode, H.N.
• Role of Cell Therapy in Neuroblastoma: Bremm, M.; Brehm, C.; Huenecke, S.; Rettinger, E.; Bader, P.
Minimal Residual Disease
• Minimal Residual Disease in Neuroblastoma: Weber, A.
• Author Index
• Subject Index
Oncology; Pediatrics; Genetics, Immunology, Neurology, Neuroendocrinology, Neurosurgery
Date de parution : 09-2015
Ouvrage de 200 p.
Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).
Prix indicatif 197,79 €
Ajouter au panierThèmes de Progressive neuroblastoma :
Mots-clés :
Pediatrics, Genetics, Immunology, Neurosurgery, Neuroendocrinology