Neurodegenerative Diseases Biomarkers, 1st ed. 2022 Towards Translating Research to Clinical Practice Neuromethods Series, Vol. 173

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Series Preface…
Preface…
Table of Contents…
Contributing Authors…

Part I Introduction

1. Prevalence, Needs, Strategies, and Risk Factors for Neurodegenerative Diseases
Philip V. Peplow, Bridget Martinez, and Thomas A. Gennarelli 

Part II Research Methods

2. Activation of Microglia and Macrophages in Neurodegenerative Diseases
Anna Salamero-Boix, Michael Schulz, and Lisa Sevenich  

3. Activation of Astrocytes in Neurodegenerative Diseases
Jiatong Li and Song Qin

4. Tau Pathology in Neurodegenerative Diseases
Thomas Vogels and Tomáš Hromádka 

5. Role of SIRT3 and Mitochondrial Dysfunction in Neurodegeneration
Jin-Hui Hor, Munirah Mohamad Santosa, and Shi-Yan Ng 

6. Oxidative Stress and Cellular Dysfunction in Neurodegeneratiove Disease
Anju Singh, Ritushree Kukreti, and Shrikant Kukreti 

7. Biomarkers in Parkinson’s Disease
Andrei Surguchov 

8. Metabolomic Biomarkers in Parkinson’s Disease
Yaping Shao, Xiaojiao Xu, Nanxing Wang, Guowang Xu, and Weidong Le  

9. Neuroinflammation in Huntington’s Disease
John D. Lee, Martin W. Lo, Jenny N.T. Fung, and Trent M. Woodruff  

10. Biomarkers in Huntington Disease
Annie Killoran

11. Biofluid Biomarkers of Amyotrophic Lateral Sclerosis
Cory J. Holdom, Frederik J. Steyn, Robert D. Henderson, Pamela A. McCombe, Mary-Louise Rogers, and Shyuan T. Ngo

12. MicroRNAs in Blood Serum, Blood Plasma, and Cerebrospinal Fluid as Diagnostic Biomarkers of Alzheimer’s Disease
Philip V. Peplow and Bridget Martinez

13. Tau Biomarkers for Long-Term Effects of Neurotrauma: Technology Versus the Null Hypothesis
Rudolph J. Castellani 

14. Impedimetric Immunosensing for Neuroinflammatory Biomarker Profiling
Andrea Cruz, Catarina M. Abreu, Paulo P. Freitas, and Inês Mendes Pinto

15. Aptamers Detection of Neurodegenerative Disease Biomarkers
Hui Xi and Yang Zhang  

16. Possible Biomarkers for Frontotemporal Dementia and to Differentiate from Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
Donald M.R. Harker, Bridget Martinez, and Ruben K. Dagda

Part III Clinical Methods

17. TSPO PET Imaging as a Biomarker of Neuroinflammation in Neurodegenerative Disorders
Eryn L. Werry, Fiona M. Bright, and Michael Kassiou 

18. Validation of Diffusion Kurtosis Imaging as an Early Stage Biomarker of Parkinson’s Disease in Animal Models
Amit Kharinar, Eva Drazanova, Nikoletta Szabo, and Jana Ruda-Kucerova  

19. Imaging Biomarkers in Huntington’s Disease
Edoardo Rosario de Natale, Heather Wilson, and Marios Politis

20. Imaging Biomarkers in Amyotrophic Lateral Sclerosis
Leonor Cerdá Alberich, Juan Francisco Vázquez Costa, Amadeo Ten-Esteve, Miguel Mazón, and Luis Marti-Bonmati 

Part IV Conclusion

21. Trends in Biomarkers of Neurodegenerative Diseases
Philip V. Peplow, Bridget Martinez, and Thomas A. Gennarelli 

Addendum…
Subject Index List…

Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts