Lynch Syndrome, 1st ed. 2020 Molecular Mechanism and Current Clinical Practice

This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition.

Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease?s manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome.

Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.

1 Molecular mechanism of Lynch syndrome.- 2 Clinical features of Lynch syndrome.- 3 Pathology of Lynch syndrome-associated tumors.- 4 Immunohistochemistry for mismatch repair proteins.- 5 Genetic analysis for Lynch syndrome.- 6 Lynch syndrome-associated gynecological malignancies​.- 7 Lynch syndrome-associated urological malignancies.- 8 Screening for Lynch syndrome.- 9 Surveillance Colonoscopy for Lynch Syndrome Patients.- 10 Surgical approach for colorectal cancer in patients with Lynch syndrome.- 11 Immunotherapy for Lynch syndrome patients.- 12 Chemoprevention for Lynch syndrome-associated malignancies.- 13 International collaboration for Lynch syndrome.

Naohiro Tomita

Professor Emeritus,

Division of Lower GI Surgery,

Department of Surgery,

Hyogo College of Medicine

Nishinomiya, Hyogo, Japan

Specially Appointed Adviser,

Cancer Treatment Center,

Toyonaka Municipal Hospital

Toyonaka, Osaka, Japan

ntomita@hyo-med.ac.jp