Endocrinology of the Heart in Health and Disease Integrated, Cellular, and Molecular Endocrinology of the Heart

Langue : Anglais

Coordonnateurs : Schisler Jonathan C., Lang Charles H, Willis Monte

Couverture de l’ouvrage Endocrinology of the Heart in Health and Disease

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Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented.

The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds.

The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.

Part I: The Heart as an Endocrine Organ

Chapter 1. Cardiac Natriuretic Peptides

Chapter 2. Adrenomedullin

Chapter 3. Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease

Chapter 4. The Cardiokines: An Expanding Family of the Heart Secretome

Chapter 5. Novel Small Peptide Hormones

Part II: The Heart as an Endocrine Target

Chapter 6. Gut-Derived Hormones—Cardiac Effects of Ghrelin and Glucagon-Like Peptide-1

Chapter 7. Fat Hormones, Adipokines

Chapter 8. Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart

Chapter 9. Renin Angiotensin Aldosterone System and Heart Function

Chapter 10. Nuclear Receptors and the Adaptive Response of the Heart

Chapter 11. Adrenergic Receptors

Chapter 12. Insulin Signaling in Cardiac Health and Disease

Jonathan Schisler has experience in studying metabolism, gene expression signatures, and ubiquitin ligases over the past 14 years. His expertise lies in integration of complex genomic-biologic data to elucidate risk relationships in both murine and human systems with a focus on cardiovascular disease and protein quality control mechanisms. His primary focus is to develop models to integrate datasets derived from clinical genomics, transcriptomics, and metabolomics allowing our lab to further interrogate gene and protein function in health and disease using molecular, cellular and biochemical approaches.
Charles H. Lang, PhD, is currently a Distinguished University Professor in the Department of Cellular and Molecular Physiology, and Professor of Surgery at the Penn State College of Medicine (Hershey, PA). He is also the Associate Dean for Graduate Studies. His research has focused on the mechanisms underlying changes in glucose and protein metabolism in skeletal and cardiac muscle, and the role of cytokines in the regulation of the insulin-like growth factor system in regulating muscle metabolism. He has worked extensively on the regulation of translational control of protein synthesis and the development of anabolic resistance during various catabolic states, including sepsis, thermal injury, disuse atrophy, alcoholism and HIV infection. Dr. Lang received his PhD from Hahnemann Medical College and did his NRSA-supported fellowship at LSU Medical Center in New Orleans. Before joining Penn State University, he was Director of Surgical Research at SUNY-Stony Brook. Dr. Lang has been continuously funded by the NIH for 30 years and is the current recipient of an NIH MERIT Award from NIAAA. He has been a permanent member of 2 NIH study sections: Surgery, Anesthesiology and Trauma, and Alcohol and Toxicology IV, and is currently the Chair of the AA-1 study section at NIH. Dr. Lang is currently the Editor-in-Chief of the American Journal of Physiology: Endocrinology an

Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease
Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically
Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology