Drug Repurposing for Emerging Infectious Diseases and Cancer, 1st ed. 2023

?This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.

Chapter 1_Repurposing of drugs: Introduction to technologies and application. - Chapter 2_The value added medicine: Pharmacovigilance re-evaluated. - Chapter 3_Polypharmacology and drug repurposing. -Chapter 4_Comparative transcriptome analysis for infectious diseases towards the identification of cellular pathways for drug repositioning. -Chapter 5_Repurposing of drugs for the treatment of microbial diseases. -Chapter 6_RNA-dependent RNA polymerase (RdRp) - a potential therapeutic approach for Coronavirus drug repositioning. -Chapter 7_Drug repurposing for emerging and re-emerging infectious diseases. -Chapter 8_Drug repurposing for the control of COVID-19.-Chapter 9_Repurposing of anti-inflammatory agents in the potential treatment of SARS 2CoV -2 infection. -Chapter 10_Repurposing of immune-modulators for the treatment of cancer with a QSAR approach. -Chapter 11_ Repurposing Cancer drugs towards antiviral targets in developing countries. -Chapter 12_Repurposed drugs for hematological malignancies. -Chapter 13_Reverse translational approach in repurposing of drugs for anticancer therapy. -Chapter 14_Repurposing of Minocycline: a tetracycline antibiotic for neurodegenerative disorders. -Chapter 15_Drug repurposing for Neglected diseases: Approaches, challenges and promising candidates.

Dr Ranbir Chander Sobti, former Vice-Chancellor Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow and former Education Advisor to the Governor of Bihar is a scientist, an able administrator and dynamic institution builder.

Starting his career as a Cytogeneticist, he moved on to molecular biology including genomics to understand the susceptibility and disease process of cancer, COPD, AIDS, metabolic syndrome and kidney diseases. He has also used Stem Cells and nanoparticles to follow the process of tissue organ development through designed decellularization protocol. Earlier he had worked on the cytogenetics and molecular genetics of various animal groups including humans as well as molecular toxicology of agricultural pollutants using in vitro and in vivo protocols.

He has published more than 350 papers in the journals of national and repute such as Mutation Research, Carcinogenesis. Archives of Toxicology, Cancer Genetics and Cytogenetics, Molecular Cell Biochemistry, PLOS I to name a few. more than 50 books by international publishers such as Springers, Academic Press, CRC, Elsevier, and others.

He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences   Canadian Academy of Cardiovascular Diseases and few others. He was the General President of Indian Science Congress Association for the 102nd session held at University of Jammu in 2013. He  is the recipient of many prestigious awards like, the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration and Sriram Oration Awards and of Life Time Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India, besides many other medals and awards of national and International levels. He was awarded Pad

Highlight different drug repositioning strategies against infectious disease and cancer

Summarizes computational approaches that are used in drug repositioning studies

Presents experimental models to validate computational methods