Biometals in Autism Spectrum Disorders
Auteur : Grabrucker Andreas
1. Introduction to Metallomics: The Science of Biometals2. Measuring Biometals3. The history of metals in autism spectrum disorders4. Essential trace metals and their function in brain development5. Non-essential metals and their brain pathology6. Biometals and nutrition in Autism Spectrum Disorders7. Linking trace metal abnormalities to Autism - insights from epidemiological studies8. The specific role of zinc in Autism Spectrum Disorder9. Animal models for trace metal abnormalities - links to Autism10. Animal models for Autism - links to biometals abnormalities11. Human stem cell models linking biometals abnormalities and Autism12. Extracerebral biometals in Autism Spectrum Disorders: the gut-brain axis13. Biometal homeostasis as therapeutic strategy in Autism Spectrum Disorders14. Future perspectives: Autism, a disorder of biometal imbalance?
- Reviews the role of trace metals in brain development
- Summarizes research linking trace metals and autism
- Explores heterogenous phenotypes as a factor of genetic and non-genetic factors
- Includes animal and human stem research
- Contains many useful diagrams, tables and flow charts
- Proposes future therapies based on biometal homeostasis
Date de parution : 07-2020
Ouvrage de 222 p.
15x22.8 cm
Thèmes de Biometals in Autism Spectrum Disorders :
Mots-clés :
AAS; Acrodermatitis enteropathica; Acute zinc deficiency; AMPAR; ASD; ASD-like behavior; Atomic absorption spectroscopy; Autism; Bacteria; Behavior; Behavioral phenotyping; Biometal; Blood–brain barrier; Brain lateralization; Cadmium; Copper; Copper overload; Deciduous tooth; Deficiency; Diet; Drug delivery; Element; Enterocytes; Epidemiological studies; Epidemiological study; Essential; Etiology; Fluorophores; Food frequency questionnaires; Gastrointestinal absorption; Glial cells; Gut; Gut–brain axis; Gut–brain signaling; Gut-brain signaling; Heavy metal pollution; IL-6; Inductively coupled plasma–mass spectrometry (ICP-MS); Inflammation; iPSC; Iron; Lead; Lipid peroxidation; Maternal immune activation; Mercury; Metaanalyses; Metalloid; Metallome; MIA; Microbiome; Microbiota; Mitochondria; Mouse models; mTOR; Nanoparticles; Neurogenesis; Neuroligin–neurexin; Neurons; NMDAR; Nutrition; Oxidative stress; Pathomechanisms; Postsynapse; Postsynaptic density; Prebiotics; Pregnancy; Prenatal; Prenatal zinc deficiency; Prenatalzinc deficiency; Prevention; Probiotics; ProSAP2; PSD; RDA; Schizophrenia; SHANK2; SHANK3; Supplementation; Synapse; Synapses; Synaptopathy; Toxic; Toxins; Trace metal; Trace metal profiles; Trace mineral; Treatment; Vitamins; VPA; Zinc; Zinc deficiency; Zinc supplementation; Zinc transport; Zincsupplements