Biomarkers in Toxicology (2^nd Ed.)

Langue : Anglais

Coordonnateur : Gupta Ramesh C

Couverture de l’ouvrage Biomarkers in Toxicology

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Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading.

Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields.

Part I. Toxicity Testing Models and Biomarkers1. Introduction2. Rodent Models for Toxicity Testing and Biomarkers3. The Göttingen Minipig as large animal model in toxicology4. Nonhuman primates in preclinical research5. Biomarkers of toxicity in zebrafish6. Mechanistic Toxicology Biomarkers in Caenorhabditis elegans7. Drosophila melanogaster, Eisenia fetida, and Daphnia magna for toxicity testing and Biomarkers 8. Alternative animal toxicity testing and biomarkers9. Adverse outcome pathways and biomarkers

Part II. Systems Toxicity Biomarkers10. Central nervous system toxicity biomarkers11. Peripheral nervous system toxicity biomarkers12. Cardiovascular toxicity biomarkers13. Respiratory toxicity biomarkers14. Hepatic toxicity biomarkers15. Conventional and emerging renal biomarkers16. Gastrointestinal toxicity biomarkers17. Reproductive toxicity biomarkers18. Biomarkers of toxicity in human placenta19. Early Biomarkers of Acute and Chronic Pancreatitis20. Skeletal muscle toxicity biomarkers21. Ocular biomarkers in diseases and toxicities22. Biomarkers of Ototoxicity23. Blood and bone marrow toxicity biomarkers24. Immunotoxicity biomarkers

Part III. Chemical Agents, Solvents and Gases Toxicity Biomarkers25. Bisphenol A (BPA) Biomarkers and Biomonitoring26. Insecticides27. Herbicides and fungicides28. Polychlorinated biphenyls, polybrominated biphenyls, and brominated flame retardants29. Polycyclic aromatic hydrocarbons30. Metals31. Melamine 32. Biomarkers of petroleum products toxicity 33. Biomarkers of chemical mixture toxicity34. Biomarkers of toxic solvents and gases

Part IV. Biotoxins Biomarkers35. Freshwater cyanotoxins 36. Mycotoxins37. Poisonous plants: biomarkers for diagnosis

Part V. Pharmaceuticals and Nutraceuticals Biomarkers38. Biomarkers of drug toxicity and safety evaluation 39. Risk Assessment, Regulation and the Role of Biomarkers for the Evaluation of Dietary Ingredients present in Dietary Supplements40. Nutriphenomics in rodent models: Impact of dietary choices on toxicological biomarkers

Part VI. Nanomaterials and Radiation41. Engineered nanomaterials: Biomarkers of exposure and effect42. Biomarkers of Exposure and Responses to Ionizing Radiation

Part VII. Carcinogens Biomonitoring and Cancer Biomarkers43. Biomonitoring exposures to carcinogens44. Genotoxicity biomarkers: Molecular basis of genetic variability and susceptibility45. Epigenetic biomarkers in toxicology46. Breast cancer biomarkers47. Pancreatic and ovarian cancer biomarkers48. Prostate cancer biomarkers

Part VIII. Disease Biomarkers49. Biomarkers of Alzheimer’s disease50. Biomarkers of Parkinson’s disease51. Biomarkers for drugs of abuse and neuropsychiatric disorders: Models and mechanisms52. Osteoarthritis biomarkers53. Pathological biomarkers in toxicology54. Oral pathology biomarkers

Part IX. Special Topics55. Biomarkers of mitochondrial dysfunction and toxicity 56. Biomarkers of blood-brain barrier dysfunction57. Biomarkers of oxidative/nitrosative stress and neurotoxicity58. Cytoskeletal disruption as a biomarker of developmental neurotoxicity59. Membrane transporters and transporter substrates as biomarkers for drug pharmacokinetics, pharmacodynamics, and toxicity/adverse events60. Citrulline: Pharmacological perspectives and role as a biomarker in diseases and toxicities

Part X. Applications of Biomarkers in Toxicology61. Analysis of toxin- and toxicant-induced biomarker signatures using microarrays62. Biomarkers detection for toxicity testing using metabolomics63. Transcriptomic biomarkers in safety and risk assessment of chemicals64. Percellome toxicogenomics project as a source of biomarkers of chemical toxicity65. Proteomics in biomarkers of chemical toxicity66. Biomarkers for Testing Toxicity and Monitoring Exposure to Xenobiotics67. Biomarkers in epidemiology, risk assessment and regulatory toxicology

Toxicologists, pharmacologists, biotechnologists, biologists, health professionals, environmental health specialists, and biomedical researchers in academic, industry and regulatory settings.

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers
Includes completely revised chapters, along with additional chapters on the newest developments in the field
Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure
Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more