Autophagy and Cardiometabolic Diseases From Molecular Mechanisms to Translational Medicine

Langue : Anglais

Auteurs : Ren Jun, Sowers James R., Zhang Yingmei

Couverture de l’ouvrage Autophagy and Cardiometabolic Diseases

Résumé
Sommaire
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Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases.

By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.

Section I. Cell biology of cardiometabolic syndrome and autophagy1. Overview of cardiometabolic syndrome2. Overview of autophagy and its molecular regulation3. Interplay among oxidative stress, redox signaling, ER-stress, autophagy and protein ubiquitination4. Selective autophagy for specific organelles5. Experimental models of autophagy and measurement of autophagy6. Role of autophagy in cardiac physiology and pathophysiology

Section II. Autophagy and pathogenesis of cardiometabolic disease7. Autophagy and diabetes mellitus8. Autophagy and hypertension9. Myocardial Insulin Signaling and Autophagy10. Autophagy and obesity11. Autophagy and dyslipidemia12. Autophagy and stroke13. Polycystic Ovary Syndrome and Cardiometabolic Disease14. Autophagy and thrombosis, vascular inflammation 15. Autophagy and Proteostasis in Cardiac Aging16. Autophagy and central nervous system

Section III. Autophagy and complications of cardiometabolic disease17. Autophagy and chronic liver disease18. Autophagy in acute and chronic kidney disease 19. Autophagy and fetal programming20. Autophagy, oxidative stress and redox regulation

Section IV. Translational approach of autophagy21. Therapeutic drug discovery targeting autophagy I22. Autophagy: A new therapeutic target23. Autophagy regulates control of intracellular energy stores24. Autophagy and epigenetics25. Autophagy, exercise and life style modification

Dr. Jun Ren, MD, PhD, FAHA, is a Professor and Associate Director in University of Wyoming Biomedical PhD Graduate Program. He is also an Adjunct Professor of Cardiology in the Department of Cardiology, Zhongshan Hospital Fudan University. He is a member of American Heart Association and Diabetes Association National Center Study Sections. Dr. Ren specializes in the molecular cardiology with the goal that is to develop a strategy to prevent cardiovascular and a better regimen of treating these disorders. Serving as PI on several federal or national grants, he has completed enormous researches arming him with experience in cardiac function and structure assessment. In addition, he successfully administered the projects (e.g. staffing, research protections, budget), supervised students, and collaborated with other researchers. He has published over 500 articles with a main research interests in Cardiovascular and neurodegenerative diseases.
James R. Sowers, MD, is Professor of Medicine, Physiology/Pharmacology and Director of the Endocrinology, Diabetes & Metabolism Division at the University Of Missouri, School Of Medicine. In addition, he is the Director of the Thomas and Joan Burns Cardiovascular and Diabetes Research Center and holds the Thomas W. and Joan F. Burns Missouri Chair in Diabetology. Dr. Sowers serves as a reviewer on several study sections for the National Institutes of Health and for the Department of Veterans Affairs. He is the editor of Cardiorenal Medicine, Associate Editor of Diabetes and on editorial boards of Hypertension, Endocrinology, and Metabolism. In the last year Dr. Sowers has published more than 25 peer-reviewed papers.
Dr. Sowers achieved the Irvin Page Lifetime Achievement Award from the American Heart Association in 2012. He serves as a PI on one NIH funded grant and a VA Merit grant, and is a Co-Investigator on several NIH grants with colleagues at the University of Missouri, as well as other research colleagues at academic

Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases
Provides knowledge from internationally recognized contributors in the field
Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases
Contains access to a companion website with additional illustrations