Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy

Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting.

1. Principles of surface-enhanced Raman spectroscopy
2. Nanoplasmonic materials for SERS
3. Experimental aspects of SERS for biological applications
4. Label free SERS for clinical applications
5. SERS nanotags design and synthesis
6. SERS for circulating biomarkers detection in clinical diagnosis
7. SERS-based microfluidic devices for in vitro diagnostics
8. SERS for sensing and imaging in live cells
9. iSERS microscopy: point-of-care diagnosis and tissue imaging
10. SERS for cancer characterization
11. Multivariate Approaches for SERS Data Analysis in Clinical Applications

Yuling Wang received her PhD from Chinese Academy of Sciences in 2009. She was then awarded an Alexander von Humboldt fellowship (2010) and the Individual Grant Fellowship from German Research Foundation (2012), working in University of Duisburg-Essen, Germany. In 2014, she received an Australian Research Council (ARC) Discovery Early Career Researcher Award (DECRA), worked in the University of Queensland (Australia). Towards the end of her ARC DECRA fellowship, she was appointed as a Senior Lecturer at Macquarie University in 2017 and was promoted to Associate Professor in 2020. She is also a Chief Investigator within ARC Excellence of Center for Nanoscale Biohotonic and leads the SERS program for in vitro diagnostics. Her research is mainly focused on plasmonic nanostructures for surface-enhanced Raman scattering/spectroscopy (SERS), biomarker sensing for point-of-care and in vitro diagnostics, and personalized nanomedicine by using SERS.