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Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds, 1st ed. 2016 Springer Theses Series

Langue : Anglais

Auteur :

Couverture de l’ouvrage Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

This thesis reports the latest developments in the direct amination of various C?H bonds using an H?Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald?s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

Electrophilic amination for the synthesis of alkyl and aryl amines.- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates.- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.-  Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation.
Born and raised in South Carolina, Stacey McDonald completed her B.S. in Chemistry from Wofford College in 2009. She then matriculated into the Chemistry Department at Duke University to pursue her Ph.D. in Organic Chemistry. While at Duke, Stacey's research focused on organic synthesis and methodology development for electrophilic aminations. She successfully defended her Ph.D. in March 2015. Stacey is currently working as a Postdoctoral Fellow at the University of North Carolina - Chapel Hill in the lab of Jeff Aubé.

Nominated as an outstanding PhD thesis by Duke University

Provides a comprehensive review of electrophilic aminations using O-benzoylhydroxylamines

Presents results which are relevant for medicinal chemistry, drug discovery and materials science

Includes supplementary material: sn.pub/extras

Date de parution :

Ouvrage de 144 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 105,49 €

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Date de parution :

Ouvrage de 144 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 105,49 €

Ajouter au panier