The Molecular Immunology of Complex Carbohydrates —2, Softcover reprint of the original 1st ed. 2001 Advances in Experimental Medicine and Biology Series, Vol. 491

This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates II, held at the Institute of Biological Chemistry, Academia Sinica, on August 28-September 1, 1999, in Taipei, Taiwan. The Editor intertwined this conference, a satellite meeting of the 15th International Glycoconjugate Conference, with a Glycobiology Workshop, resulting in one of the most comprehensive handbooks on carbohydrate specificities of applied lectins and anti- carbohydrate monoclonal antibodies in the field. The proceedings provide information on glycotopes required for essential basic concepts and applications. It will be a useful tool for researchers and beginners in the fields of immunology, biochemistry, cancer research, and structural biology for years to come.

SECTION I Carbohydrate-Protein Interactions: Plant and Animal Lectins.- I-1 The Structural Basis for Carbohydrate Recognition by Lectins.- I-2 Lectin Cross-linking Interactions with Multivalent Carbohydrates.- I-3 Classification of Plant Lectins in Families of Structurally and Evolutionary Related Proteins.- I-4 Expression of Binding Properties of Gal/Ga1NAc Reactive Lectins by Mammalian Glycotopes.- I-5 ‘Glyco-Epitope’ Assignments for the Selectins: Advances Enabled by the Neoglycolipid Technology in Conjunction with Synthetic Carbohydrate Chemistry.- I-6 Animal Lectins: From Initial Description to Elaborated Structural and Functional Classification.- I-7 Galectins and Other Endogenous Carbohydrate-Binding Proteins of Animal Bladder.- I-8 Binding Properties and Applications of Aplysia Gonad Lectin.- I-9 Lectin and Anti-carbohydrate Antibody Assays Using Chemically Modified Ligands.- SECTION II Structure and Antigenicity of Glycoconjugates.- II-1 Intramolecular Carbohydrate-Protein Interaction.- II-2 Red Blood Cell Antigens Responsible for Inherited Types of Polyagglutination.- II-3 Antigenic Properties of Human Glycophorins—An Update.- II-4 KDN-Containing Glycoprotein from Loach Skin Mucus.- II-5 Glycoconjugates from Parasitic Helminths: Structure Diversity and Immunobiological Implications.- II-6 Glycosyl Phosphatidylinositol-Linked Glycoconjugates: Structure, Biosynthesis, and Function.- II-7 Enzymatic and Chemical Approaches for the Synthesis of Sialyl Glycoconjugates.- SECTION III Glycotopes Expression, Metabolism, and Functions.- III-1 The Genetic Regulation of Fucosylated and Sialylated Antigens on Developing Myeloid Cells.- III-2 Transcriptional Regulation of Expression of Carbohydrate Ligands for Cell Adhesion Molecules in the Selectin Family.- III-3Biosynthesis and Function of ?1,6 Branched Mucin-Type Glycans.- III-4 Differentiation-Associated Expression of ß-N-acetylgalactosaminylated N-linked Oligosaccharides in Mammary Epithelial Cells.- III-5 Metabolism and Role of O-Acetylated Sialic Acids.- III-6 Contradictory Functions of the Sulfatide in the Blood Coagulation System.- III-7 Interaction of GM2 Activator Protein with Glycosphingolipids.- SECTION IV Complex Carbohydrates in Development and Treatment of Cancer.- IV-1 Tumor-Associated Carbohydrate Antigens Defining Tumor Malignancy: Basis for Development of Anti-cancer Vaccines.- IV-2 Carbohydrate-Mediated Adhesion of Human Colon Carcinoma Cells to Human Liver Sections.- IV-3 O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of c-Myc.- IV-4 Analysis of a Murine Anti-Ganglioside GD2 Monoclonal Antibody Expressing Both IgG2a and IgG3 Isotypes: Monoclonality, Apoptosis Triggering, and Activation of Cellular Cytotoxicity on Human Melanoma Cells.- SECTION V Complex Carbohydrates in Microbial and Viral Infections and Vaccine Design.- V-1 Pathogen-Host Protein-Carbohydrate Interactions as the Basis of Important Infections.- V-2 Host Mediated Variation and Receptor Binding Specificity of Influenza Viruses.- V-3 Bacterial Polysaccharides as Vaccines — Immunity and Chemical Characterization.- V-4 The Conformational Epitope of Type III Group B Streptococcus Capsular Polysaccharide.- V-5 T-independent IgA Responses to Microbial Polysaccharides.- V-6 Protective Immunity and Gene Expression Related to Pneumococcal Glycoconjugates.- V-7 Structure and Functional Genomics of Lipopolysaccharide Expression in Haemophilus influenzae.- V-8 Molecular Mimicry of Host Structures by Lipooligosaccharides of Neisseria meningitidis: Characterization ofSialylated and Nonsialylated Lacto-N-Neotetraose (Gal?1-4G1cNAc?1-3Gal?1-4Glc) Structures in Lipooligosaccharides using Monoclonal Antibodies and Specific Lectins.- V-9 NMR and Molecular Modeling of Complex Carbohydrates and Carbohydrate-Protein Interactions: Applications to Anti-bacteria Vaccines.- Append.- A-I A Guide to the Carbohydrate Specificities of Applied Lectins-2 (Updated in 2000).- A-II A Guide to Monoclonal Antibodies Directed to Glycotopes.