Systems and Synthetic Biology, 2015

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology ? in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Introduction to Systems Biology.- Why Systems Biology Can Promote a New Way of Thinking.- Modelling Methodologies for Systems Biology.- In silico Identification of Eukaryotic Promoters.- Hill Equation in Modeling Transcriptional Regulation.- Molecular Modeling.- Complex Networks and Systems Biology.- Systems Biology of Infectious Diseases.- Systems Pharmacology and Pharmacogenomics for Drug Discovery and Development.- Switching Mechanism in the p53 Regulatory Network.- Systems Biology of Micro RNA.- A Brief Introduction to Synthetic Biology.- DNA Structure and Promoter Engineering.- Synchronous Sequential Computations with Biomolecular Reactions.- Designing Zinc Finger Proteins for Applications in Synthetic Biology.- Synthetic Biology for the Development of Biodrugs & Designer Crops and the Emerging Governance Issues.- Recent Advancement of Emerging Tools in Synthetic Biology for the Designing and Characterization of Genetic Circuits.- Metabolic Engineering of Microorganisms for Biosynthesis of Antibiotics.- DNA Origami: What, How and Where.- Making Synthetic Proteins from Non-coding DNA.- Engineering Biological Systems: A Brief Overview.

Comprehensive and in-depth treatment of fundamental concepts In each chapter, a balance between the various ideas introduced and their applications to the research problems Detailed design strategies of biological systems A special chapter about the ethics, legality and safety issues in Synthetic Biology Includes supplementary material: sn.pub/extras