Structural Genomics on Membrane Proteins
Coordonnateur : Lundstrom Kenneth H.
While the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins. This discrepancy becomes significantly troublesome when it is coupled with the fact that 60 percent of current drugs are based on targeting this group of proteins, a trend that does not seem likely to reverse.
Structural Genomics on Membrane Proteins provides an excellent overview on novel research in bioinformatics and modeling on membranes, as well as the latest technological developments being employed in expression, purification, and crystallography to obtain high-resolution structures on membrane proteins. This cutting-edge work also explains the difficulties facing researchers?both technical and ethical?that have slowed the process.
Structural Genomics on Membrane Proteins provides researchers with an unprecedented look at the novel technologies that will ultimately allow them to conquer the last frontier in structural biology, leading to accelerated breakthroughs in drug discovery.
Date de parution : 10-2019
15.6x23.4 cm
Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).
Prix indicatif 74,82 €
Ajouter au panierDate de parution : 02-2006
Ouvrage de 384 p.
15.6x23.4 cm
Thèmes de Structural Genomics on Membrane Proteins :
Mots-clés :
Membrane Proteins; Structural Biology; Integral Membrane Proteins; Recombinant Membrane Proteins; Crystallization Trials; SFV; Structure Based Drug Design; Solution NMR; Structural Genomics Initiatives; Structural Genomics; Baculovirus Insect Cell Expression System; Light Harvesting Complex; Soluble Membrane Protein; Detergent Micelles; Fluorescence Resonance Energy Transfer; Fret; Ligand Binding Domains; MFS Protein; Helix VI; Baculovirus Insect Cell System; GABA Transporter; Ion Channel; Baculovirus Insect Cell; Multiple Sequence Alignments; Acyl Carrier Protein