Raynaud’s Phenomenon, 2015 A Guide to Pathogenesis and Treatment

Raynaud?s Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike. In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud?s Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies. Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular perturbation that mimics RP, this title provides a wealth of new information available on normal and abnormal thermoregulation and helps physicians identify the best therapeutic approaches to treating RP. The work offers differential diagnosis options, reviews potential causes such as autoimmune disease, industrial trauma, drugs, and metabolic causes and provides clear recommendations for therapy. Engaging readers with case vignettes and a plethora of visual aids, Raynaud?s Phenomenon: A Guide to Pathogenesis and Treatment is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to physicians, patients, and individuals dealing with these disease processes.

​Historical perspective of Raynaud's phenomenon.- definition, nomenclature and diagnostic criteria.- Epidemiology of Raynaud’s Phenomenon.- Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular System.- Pathophysiological Regulation of the Cutaneous Vascular System in Raynaud’s Phenomenon.- Primary Raynaud’s Phenomenon.- Raynaud Phenomenon In The Pediatric Age.-Secondary Raynaud’s phenomenon.- Traumatic Vasospastic Disease.- Other Secondary Causes.- Raynaud’s Mimics.- Nailfold Capillaries.-Non-Invasive methods of assessing Raynaud’s phenomenon.- Angiography.- Autoantibodies in Raynaud’s Phenomenon.- Systemic Vasospasm.- Clinical Outcome Measures in Raynaud’s Phenomenon.- Design and reporting of randomised controlled trials for Raynaud’s phenomenon.- Non-drug Approaches to Treating Raynaud’s Phenomenon.- Drug Treatment of Raynaud’s Phenomenon.- Management of digital ischemia.- Surgical Management.- Practical Approaches to Treatment: Case Studies.

Fredrick M. Wigley, M.D.

Johns Hopkins University

School of Medicine

Baltimore, MD

USA

Ariane L. Herrick, M.D., FRCP

University of Manchester,

Salford Royal NHS Foundation,

Manchester Academic Health Science Centre,

Manchester,

UK

Nicholas Flavahan, Ph. D.

Johns Hopkins University

School of Medicine

Baltimore, MD  

USA