Quinones and Quinone Enzymes, Part B

Section I: Mitochondrial Ubiquinone and Reductases

1: Mitochondrial Quinone Reductases: Complex I

2: Q-Cycle Bypass Reactions at the Q_o Site of the Cytochrome bc₁ (and Related) Complexes

3: Targeting Coenzyme Q Derivatives to Mitochondria

4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia

5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency

6: Coenzyme Q Cytoprotective Mechanisms

7: Dietary Coenzyme Q₁₀ and Mitochondrial Status

Section II: Anticancer Quinones and Quinone Oxidoreductases

8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics

9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)

10: Diaziridinylbenzoquinones

11: Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications

12: Bioactivation and Resistance to Mitomycin C

13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells

14: The “Prochaska” Microtiter Plate Bioassay for Inducers of NQO1

15: Structure-Activity Relationships in Two-Electron Reduction of Quinones

16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1

17: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases

18: Induction of NQO1 in Cancer Cells

Section III: Quinone Reductases: Chemoprevention and Nutrition

19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates

20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase

21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens

22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes

23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview

25: Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli

Section IV: Quinones and Age-Related Diseases

26: Therapeutic Effects of Coenzyme Q₁₀ in Neurodegenerative Diseases

27: Neuroprotective Actions of Coenzyme Q₁₀ in Parkinson's Disease

Author Index

Subject Index

• Mitochondrial Ubiquinone and Reductases
• Anticancer Quinones and Quinone Oxido-Reductases
• Quininone Reductases: Chemoprevention, Nutrition
• Quinones and Age-Related Diseases