Quantitative modeling in toxicology (Paper)
Auteurs : KRISHNAN Kannan, ANDERSEN Melvin
About the Editors
About the Book
List of Contributors
Section1: Introduction
Chapter 1 Quantitative modeling in toxicology: An introduction
Melvin E. Andersen and Kannan Krishnan
Section2: Physiologically-based toxicokinetic and pharmacokinetic (PBPK) modeling
Chapter 2 PBPK modeling: a primer
Kannan Krishnan, George Loizou, Martin Spendiff, John Lipscomb and Melvin E. Andersen
Chapter 3 Pharmacokinetic modeling with Manganese - An essential element
Andy Nong, Michael Taylor, Miyoung Yoon, and Melvin E. Andersen
Chapter 4 Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures
Sami Haddad, Robert Tardif, Jonathan Boyd, and Kannan Krishnan
Chapter 5 Physiological Parameters and Databases for PBPK Modeling
Douglas O. Johns, Elizabeth Oesterling Owens, Chad M. Thompson, Babasaheb Sonawane, Dale Hattis and Kannan Krishnan
Section3: Modeling toxicant-target interactions
Chapter 6 Modeling cholinesterase Inhibition
Charles Timchalk, Paul M. Hinderliter,and Torka S. Poet
Chapter 7 Modeling of Protein Induction and dose-dependent hepatic sequestration
Andy Nong and Melvin E. Andersen
Chapter 8 Bistable Signaling Motifs and Cell Fate Decisions
Sudin Bhattacharya, Qiang Zhang, and Melvin E. Andersen M.E.
Chapter 9 Ultrasensitive Response Motifs in Biochemical Networks
Qiang Zhang, Sudin Bhattacharya, Courtney G. Woods, and Melvin E. Andersen
Chapter 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks
Melvin E. Andersen, Qiang Zhang, and Sudin Bhattacharya
Chapter 11 Modeling Kidney and Liver Cytotoxicity
Kai H. Liao, Yu-Mei Tan, Harvey J. Clewell III, and Melvin E. Andersen
Section4: Modeling tissue and organism responses
Chapter 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat
Jeffrey W. Fisher and Eva D. McLanahan
Chapter 13 Two Stage Clonal Growth Modeling of Cancer
Rory B. Conolly and Melvin E. Andersen
Chapter 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures
Hisham A. El-Masri, Michael A. Lyons, and Raymond S.H. Yang
Chapter 15 (Q)SAR Models of Adverse Responses: Acute Systemic Toxicity
Mark T.D. Cronin, Yana K. Koleva, and Judith C. Madden
Section5: Model application and evaluation
Chapter 16 Modeling Exposures to Chemicals from Multiple Sources and Routes
Panos G. Georgopoulos, Sastry S. Isukapalli, and Kannan Krishnan
Chapter 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data
Yu-Mei Tan and Harvey J. Clewell III
Chapter 18 Quantitative Modeling in Noncancer Risk...
Date de parution : 04-2010
Ouvrage de 496 p.
24.4x16.8 cm
Disponible chez l'éditeur (délai d'approvisionnement : 12 jours).
Prix indicatif 165,11 €
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