Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Auteur : Seneci Pierfausto
Aimed at "drug discoverers" ? i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular ? the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects?2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where’s the baby?4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure6. Assembly and disassembly of protein aggregates: Unraveling the maze
- Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
- Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
- Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
- Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
- Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
Date de parution : 10-2014
Ouvrage de 314 p.
15.2x22.8 cm
Thèmes de Molecular Targets in Protein Misfolding and... :
Mots-clés :
α-synuclein; Aβ; acetylation; aggregation; aggregation inducers; aggrephagy; aggrephagy receptors; aggrephagy scaffolds; aggrephagy transporters; aggresomes; Alzheimer's disease; amphisomes; amyloid fibers; Atg5-Atg12 complex; Atg8-phosphatidylethanolamine complex; autolysosomes; autophagosomes; autophagy; BAG co-chaperones; BAG-1; cdc37; chaperone-assisted selective autophagy (CASA); chaperone-mediated autophagy (CMA); CHIP; cholesterol; CK2 class III PI3K complex; co-chaperones; de-ubiquitinases; disaggregation; disease-modifying therapies; E1 activating enzymes; E2 conjugating enzymes; endocytosis; endosomes; FKBP51; FKBP52; gangliosides; HDAC6 heat shock proteins; HECT E3 ligases; Hsp104 complex; Hsp110 Hsp27; Hsp70; Hsp90; huntingtin; intrinsically disordered proteins; isopeptides; lipid membranes; lipid rafts; lysosomes; macropinocytosis; mature fibrils; molecular chaperones; mTORC1 complex; neurodegeneration; nuclear exchange factors; off-pathway processes; oligomer species; p62; phagophores; phospholipids; phosphorylation; post-translational modifications; prion protein proteasome; protein folding; protein quality control; protein refolding; protofibrils; RBR E3 ligases; RING E3 ligases; selective autophagy; small Hsps; small molecule enhancers of autophagy tau; tauopathies; ubiquitin; UCH37 ULK complex; Usp14