Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2, Softcover reprint of the original 1st ed. 1998 Basic Science and Clinical Relevance Advances in Experimental Medicine and Biology Series, Vol. 438

During the past two decades, a significant international research effort has been di­ rected toward understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays an essential role in maintaining corneal and conjunctival integrity, protecting against microbial challenge, and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in countless individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perfo­ ration of the cornea, an increased incidence of infectious disease, and, potentially, pro­ nounced visual disability and blindness. To promote further progress in this field of vision research, the Second International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance was held at the Southampton Princess Resort in Bermuda November 16-19, 1996. This conference was organized and directed by David A. Sullivan, Ph. D. , codirected by Darlene A. Dartt, Ph. D. , and Michele A. Meneray, Ph. D. , and sponsored by the Schepens Eye Research Institute (Boston, MA), an affiliate of Harvard Medical School. The meeting was designed to assess critically the current knowledge and "state of the art" research on the structure and function of lacrimal tissue, tears, and the ocular sur­ face in both health and disease.

Conference Address.- Lacrimal Gland: Cellular and Molecular Biology.- Lacrimal Gland and Ocular Surface: Signal Transduction, Membrane Traffic, and Fluid and Protein Secretion.- Mucins: Origin, Biochemistry, and Regulation.- Meibomian Gland and Tear Film Lipids: Structure, Function, and Control.- Tear Film Stability, Evaporation, and Biophysics.- Cytokines, Growth Factors, Proto-Oncogenes, and Apoptosis.- Inflammation and Immunity.- Tear Film Components and Influence on the Ocular Surface.- Artificial Tears and Contact Lenses: Impact on the Tear Film and Ocular Surface.- Classification, Diagnosis, Clinical Features, and Epidemiology of Dry Eye Syndromes.- Pathogenesis of Dry Eye Syndromes.- Management and Therapy of Dry Eye Syndromes.- Contributors.