Hypoxia, Softcover reprint of the original 1st ed. 1999 Into the Next Millennium Advances in Experimental Medicine and Biology Series, Vol. 474

Hypoxia is a constant threat throughout life. International experts from many different fields, including clinicians, clinical researchers, and basic scientists, have contributed to this volume, presenting state-of-the-art information regarding normal and abnormal (pathophysiological) responses to hypoxia. The topics covered include visitors to high altitude, the latest developments on high-altitude cerebral and pulmonary edema, the brain in hypoxia, high-altitude headache, and similarities between ischemic and hypoxic injury to the brain. In addition topics are covered such as blood-brain barrier in hypoxia, hypoxia interactions with vascular growth, and how humans adjust to extreme hypoxia.

Mountain Medicine.- 1. Herb Hultgren in Peru: What Causes High Altitude Pulmonary Edema?.- 2. High Altitude Cerebral Edema and Acute Mountain Sickness: A Pathophysiology Update.- 3. Lung Disease at High Altitude.- 4. Commuting to High Altitude.- 5. The Pregnant Altitude Visitor.- High Altitude Pulmonary Edema.- 6. High Altitude Pulmonary Edema: Introduction.- 7. Pulmonary Hemodynamics: Implications for High Altitude Pulmonary Edema (HAPE).- 8. High-Altitude Pulmonary Edema: From Exaggerated Pulmonary Hypertension to a Defect in Transepithelial Sodium Transport.- Frontiers in Neuroscience: The Blood-Brain Barrier.- 9. Hypoxia and the Blood-Brain Barrier: Introduction.- 10. What is the Blood-Brain Barrier? A Molecular Perspective.- 11. Mediators of Cerebral Edema.- Frontiers in Neuroscience: The Hypoxic Brain.- 12. The Hypoxic Brain: Introduction.- 13. High Altitude Headache.- 14. The Hypoxic Brain: Insights from Ischemia.- 15. Food for Thought: Altitude versus Normal Brain Function.- Hypoxia and Lactate: New Insights.- 16. Are Arterial, Muscle and Working Limb Lactate Exchange Data Obtained on Men at Altitude Consistent with the Hypothesis of an Intracellular Lactate Shuttle?.- 17. Role of Pyruvate Dehydrogenase in Lactate Production in Exercising Human Skeletal Muscle.- 18. Cross-Species Studies of Glycolytic Function.- Hypoxia and Regulation of Vascular Growth.- 19. Hypoxia Induces Cell-Specific Changes in Gene Expression in Vascular Wall Cells: Implications for Pulmonary Hypertension.- 20. Oxygen and Placental Vascular Development.- 21. Vascular Growth in Hypoxic Skeletal Muscle.- Human Physiology in Extreme Hypoxia.- 22. Recent Advances in Human Physiology at Extreme Altitude.- 23. Operation Everest III (COMEX ’97).- 24. Dynamic Cerebral Autoregulation at HighAltitude.- 25. Kangchenjunga 1998.- 26. Why Does the Exercise Cardiac Output Fall During Altitude Residence and is It Important?.- Chronic Mountain Sickness Consensus Group.- 27. International Consensus Group on Chronic Mountain Sickness.- Tribute to Niels Lassen.- 28. Niels Lassen.- Abstracts.- 29. Abstracts from the 11th International Hypoxia Symposium.- Author Index.