Hematopoietic Cell Transplantation in Children with Cancer, 2014 Pediatric Oncology Series

This book is a comprehensive and up-to-date compendium on all aspects of blood and marrow transplantation in children. After an introductory chapter describing the history of pediatric blood and marrow transplantation, subsequent chapters discuss pediatric-specific aspects of transplantation, including stem cell sources suitable for transplantation, preparative regimens, graft-versus-host disease, complications related to transplantation, and late effects. The role of blood and marrow transplantation in various specific pediatric diseases is then examined, and the closing chapter considers future directions. The authors are all internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric diseases that are treatable with blood and marrow transplantation and will prove invaluable to specialists, generalists, and trainees alike.

History of Pediatric BMT.- Stem Cell Sources and Donor Selection.- Preparative Regimens.- Graft-versus-Host Disease.- Complications Following BMT and Supportive Care.- Late Effects.- Acute Lymphoblastic Leukemia.- Acute Myeloid Leukemia.- Lymphomas.- Myelodysplastic and Myeloproliferative Disorders.- Solid Tumors.- Non-Malignant Diseases.- Future Directions.

Franklin Oscar Smith, III, gained his MD from the University of South Carolina School of Medicine, Columbia in 1984, having previously obtained a B.S. in Chemistry, cum laude, from Wofford College, Spartanburg, South Carolina. Professor Smith served as the Director of the Pediatric Stem Cell Transplantation Program at Riley Hospital for Children at the Indiana University School of Medicine from 1997 until 2001 when he appointed as the Director of the Division of Hematology/Oncology at Cincinnati Children’s Hospital Medical, serving in this role until 2010.  Since 2001 he has been Marjory J. Johnson Endowed Chair in Pediatric Hematology/Oncology and Professor of Pediatrics, with Tenure, at the Cincinnati Children’s Hospital Medical Center, University of Cincinnati.  He is also currently Interim Director of the Bone Marrow Transplantation Program and Associate Director of the Hematology/Oncology Fellowship Training Program in the Department of Internal Medicine, University of Cincinnati College of Medicine. He has been the recipient of many awards and honors, including a Distinguished Physician Alumni Award from the University of South Carolina School of Medicine, Alpha Omega Alpha membership, a Distinguished Service Award from the Children’s Oncology Group, the Amanda Toll Endowed Lectureship, and the Ronald Chard Endowed Lectureship. Professor Smith was the Vice-Chair of the Children’s Oncology Group, was a member of the Board of Directors of the Foundation for the Accreditation of Cellular Therapy as a member of the Medical and Scientific Affairs Committee of the Leukemia and Lymphoma Society. He has served on many National Institutes of Health and Food and Drug Administration ad hoc committees. Professor Smith has served on the editorial boards of several journals, including the British Journal of Haematology. He has authored or co-authored more than 100 peer-reviewed articles and reviews, many book chapters, editorials, and commentaries and a recent textbook on