Defects of Secretion in Cystic Fibrosis, 2005 Advances in Experimental Medicine and Biology Series, Vol. 558

Outside Neurons/Inside Epithelia: Novel Activation of CFTR Cl? and HCO3 ? Conductances.- Role of CFTR and Other Ion Channels in Cystic Fibrosis.- Ion Channels in the Apical Membrane: Role of Electrical Coupling on Transepithelial Transport.- Ion Channels in Secretory Granules of the Pancreas: Molecular Identification and Their Role in Regulated Secretion.- Epithelial Transport and Intracellular Trafficking: Physiology and Pathophysiology.- Kinases, Cell Volume, and the Regulation of Chloride Channels.- The CLCAs: Proteins with Ion Channel, Cell Adhesion and Tumor Suppressor Functions.- Is Intervention in Inositol Phosphate Signaling a Useful Therapeutic Option for Cystic Fibrosis?.- An Inositol Phosphate Analog, INO-4995, Normalizes Electrophysiology in CF Airway Epithelia.- Vitamin C and Flavonoids Potentiate CFTR Cl Transport in Human Airway Epithelia.- Airway Glycoconjugates Secreted in Cystic Fibrosis and Severe Chronic Airway Inflammation Relationship with Pseudomonas aeruginosa.- Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic Fibrosis.

Brings together research that will be of interest to physicians, physiologists and other scientists involved in basic research, from molecular biology to drug design Presents the most recent updates in novel investigative and therapeutic aspects of secretion disorders relevant in cystic fibrosis and other related diseases Brings basic and clinical research closer together Includes supplementary material: sn.pub/extras