Computational Systems Biology (2nd Ed.) From Molecular Mechanisms to Disease
Coordonnateurs : Kriete Andres, Eils Roland
Introducing Computational Systems Biology; Protein Interactions, Stability and Regulation; Transcriptional control; Introduction to Computational Models of Biochemical Reaction Networks; Biological Foundations of Signal Transduction and Aberrations in Disease; A discrete approach to top-down modeling of biochemical networks; Reconstruction of metabolic network from genome information and its structural and functional analysis; Gene networks: estimation, modeling and simulation; Standards, platforms and tools; Computational models for circadian rhythms: Deterministic versus stochastic approaches; Integrated imaging informatics; Imaging and Modeling of complex tumor formation; Imaging to help decipher an model higher orders of complexity; Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks; Whole Cell Modeling; Databases for Systems Biology; Systems Biology of the Microbiome; Systems Immunology; Applying systems biology to understand the immune response to infection and vaccination; Aging and Systems Biology; From Cardiac Mitochondria to Systems Physiology; Cancer Systems Biology; Systems Medicine, Drug Biology and Interventions; Towards a blueprint of an entire organism
Professor of Bioinformatics at the University of Heidelberg and Director of the Division of Theoretical Bioinformatics at the German Cancer Research Center (DKFZ) in Heidelberg
- Logical information flow aids understanding of basic building blocks of life through disease phenotypes
- Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns
- Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation
- Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Date de parution : 01-2014
Ouvrage de 548 p.
19x23.3 cm
Thème de Computational Systems Biology :
Mots-clés :
information; logical; disease phenotypes; principles; organization; biological; biology; processes; adaptation; response; patterns; technical; modeling; scales; dependencies; spatio-temporal